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Therapeutic strategies to deplete macrophages in atherosclerotic plaques


, : Therapeutic strategies to deplete macrophages in atherosclerotic plaques. British Journal of Clinical Pharmacology 74(2): 246-263

Macrophages can be found in all stages of atherosclerosis and are major contributors of atherosclerotic plaque development, progression and destabilization. Continuous recruitment of monocytes drives this chronic inflammatory disease, which can be intervened by several strategies: reducing the inflammatory stimulus by lowering circulating lipids and promoting cholesterol efflux from plaque, direct and indirect targeting of adhesion molecules and chemokines involved in monocyte adhesion and transmigration, and inducing macrophage death in atherosclerotic plaques in combination with anti-inflammatory drugs. This review discusses the outlined strategies to deplete macrophages from atherosclerotic plaque to promote plaque stabilization.

US$19.90

PMID: 22309283

DOI: 10.1111/j.1365-2125.2012.04211.x


Other references

Burkhart, Stephen, S., 1995: The Deadman Theory of Suture Anchors: Observations Along a South Texas Fence Line. Suture anchors are being increasingly reported as a means of fixation of torn rotator cuff tendons to bone. The author has developed a mechanical model for the suture anchor-rotator cuff construct based on an analogy to the deadman system used to...

Tomino, Y., 2004: Relationship between the serum IgA/C3 ratio and the progression of IgA nephropathy. Internal Medicine 43(11): 1011-1011

Dunn, A.W.; Russo, C.L., 1973: Central acetabular fractures. Journal of Trauma 13(8): 695-705

Boroskova, Z.; Soltys, J.; Benkova, M., 1996: Effect of copper on the immune responses of guinea pigs with experimental ascaridiosis. Guineapigs of 250-300 g body weight were allotted to 3 groups: 83 were given CuSO4 daily at 2080 micro g/kg for 28 days, 44 of which were then given 3000 Ascaris suum eggs the day after the end of CuSO4 administration (the other 39 were non-infect...

Amosov, N.M.; Datsenko, N.Ia., 1983: Heart valve prosthesis after mitral commissurotomy. Khirurgiia: 5-8

Krishnamoorthy, A.; Mani, M., 1998: New record of parasitoid Diadegma apostata (G.) on brinjal shoot and fruit borer. During a survey for natural enemies of Leucinodes orbonalis on aubergine in India, Diadegma apostata was recorded from the pest for the first time. Brief notes are given on its biology.

Martin, S.; Zimprich, D.; Oster, P.; Wahl, H.W.; Minnemann, E.; Baethe, M.; Gruen, U.; Martin, P., 2000: Success and success variability of geriatric rehabilitation: An empirical study based on medical-geriatric as well as psychosocial indicators. This study considers findings of psychological gerontology as particularly important for geriatric rehabilitation research. Its concrete aim was to describe the course and outcome of geriatric rehabilitation based on a wide range of success criter...

Alberdi, MT.; Ortiz Jaureguizar, E.; Prado, JL., 2001: Comments on Equus species as stratigraphic markers. Reality or wishful thinking? and A review of Equus stenonis Cocchi (Perissodactyla, Equidae) and related forms by A. Forsten. Quaternary Science Reviews. April; 2010: 1149-1151

Siligato, Simonetta., 1999: A contribution to the autecology of Balons ruffe Gymnocephalus baloni Holcik Hensel, 1974 Beitrage zur Autokologie des Donaukaulbarsches Gymnocephalus baloni Holcik Hensel, 1974. Verhandlungen der Gesellschaft fuer Ichthyologie (GfI) e V. 1998( ); 1: 211-217

Frost, H.; Braun, D.G.; Poskitt, D.; Cahill, R.N.; Trnka, Z., 1976: Antipolysaccharide antibodies of restricted heterogeneity secreted by a single lymph node. Immune responses which give rise to the synthesis of antibodies of restricted heterogeneity can be reproducibly induced in rabbits and mice by streptococcal polysaccharide antigens (1,2). While these reports have demonstrated clonotype restriction...