geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Anti-CD2 rituximab therapy for anti-IFN-gamma autoantibody-associated nontuberculous mycobacterial infection


, : Anti-CD2 rituximab therapy for anti-IFN-gamma autoantibody-associated nontuberculous mycobacterial infection.

Patients with anti–IFN- autoantibodies have impaired IFN- signaling, leading to severe disseminated infections with intracellular pathogens, especially nontuberculous mycobacteria. Disease may be severe and progressive, despite aggressive treatment. To address the underlying pathogenic IFN- autoantibodies we used the therapeutic monoclonal rituximab (anti-CD2) to target patient B cells. All subjects received between 8 and 12 doses of rituximab within the first year to maintain disease remission. Subsequent doses were given for relapsed infection. We report 4 patients with refractory disease treated with rituximab who had clinical and laboratory evidence of therapeutic response as determined by clearance of infection, resolution of inflammation, reduction of anti–IFN- autoantibody levels, and improved IFN- signaling.

US$29.90


Other references

Mizrokhi L.Yu; Mazo A.M.; Karavanov A.A.; Sedkov Y.A.; Krichevskaya A.A.; Il'in Y.V., 1989: Mutations in drosophila due to the insertion of mdg4 are suppressed by the interaction of the products of the su hw and su f genes with the region of mdg4 which regulates its transcription. The mdg4 (gypsy) mobile element of Drosphila contains two closely situated regions binding to proteins from nuclear extracts. One of these is an imperfect palindrome having homology with the lac operator of Escherichia coli, the other contains a r...

Thorsen, R., 1999: An artefact suppressing fast-recovery myoelectric amplifier. An amplifier for recording myoelectric signals using surface electrodes has been developed. The special features are suppression of stimulation artefacts and motion artefacts from electrodes. It is designed for recording of myoelectric signals fro...

Chappell, M.A.; Miller, L.F.; George, A.J.; Pettway, B.A.; Price, C.L.; Porter, B.E.; Bednar, A.J.; Seiter, J.M.; Kennedy, A.J.; Steevens, J.A., 2011: Simultaneous dispersion-dissolution behavior of concentrated silver nanoparticle suspensions in the presence of model organic solutes. The premise of the nanotechnology revolution is based on the increased surface reactivity of nanometer-sized particles. Thus, these newly realized applications of noble metal nanoparticles introduce new concerns about the environmental fate of the...

Marks, J., 1986: Barbecues. The number of public houses and clubs etc. featuring barbecuing has greatly increased. Those deciding whether to set up a barbecue facility need to consider the capital investment required, running costs, promotional efforts, advertising expenditu...

Sinitsyna, A.L.; Lashas, L.V.; Zarubina, N.A.; Evaltaite, D.; Aleshina, L.V., 1977: Physicochemical characteristics and biological activity of human somatotropin preparation. The 1st Soviet growth hormone preparation, human somatotropin for injections, was obtained. It was nontoxic and possessed a high biological [bacteria, viruses and rats] activity (0.9-1.2 U/mg). It can be used in the therapy of hypophysial and cere...

Godoy,C.V.; Henning,A.A., 2008: Seed treatment and foliar fungicide application to control soybean rust. An experiment was conducted to evaluate the effect of soyabean seed treatment with fluquinconazole and foliar fungicide application on soyabean rust management, in three sowing dates, during the 2007/08 growing season, in Londrina, Parana, Brazil....

Konopacki, F.A.; Rylski, M.; Wilczek, E.; Amborska, R.; Detka, D.; Kaczmarek, L.; Wilczynski, G.M., 2007: Synaptic localization of seizure-induced matrix metalloproteinase-9 mRNA. The phenomenon of dendritic transport and local translation of mRNA is considered to be one of the most fundamental mechanisms underlying long-term synaptic plasticity. Matrix metalloproteinase 9 (gelatinase 13) (MMP-9) is a matrix metalloproteina...

Figueiredo J.M.D.; Pereira J.L.; Lellis W.T.; Luz E.D.M.N., 1985: Mixtures of systemic fungicides as protectives in the control of brown rot. Fitopatologia Brasileira 10(2): 280

Arora, R.R.; Biswas, H.; Mathur, K.K.; Wattal, B.L., 1977: Amoebiasis in India. From a review of reports from different parts of India it is considered that the endemicity of amoebiasis ranges from one to 58%. The higher prevalence rates have been recorded from Maharashtra, Tamil Nadu and Chandigarh. There are 40 references.

Anonymous, 1981: Adult education in Quebec: hypotheses and solutions. This working document concerns policy for adult education both in terms of trainers and the problems particularly relevant to adults. The academic and working environments are studied. Distance education, community education and the financing of a...