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Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention


, : Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention.

The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails, and regulation by non-coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies provide evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one carbon metabolism such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine, and methionine, affect DNA methylation by regulating levels of S-adenosyl-L-methionine, a methyl group donor, and S-adenosyl-L-homocysteine which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non-coding RNAs such as vitamin D that recruits histone acetylases or resveratrol that activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro-RNAs. Since epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti-cancer therapy.

US$19.90

DOI: 10.1111/j.1476-5381.2012.02002.x


Other references

Cassens, D.; Feist, W., 1980: Finishing and maintaining wood floors. North Central regional extension ication: 80 (136)

Berry, I.; Cassol, E.; Ibarrola, D.; Manelfe, C.; Clanet, M., 2001: New MRI techniques in multiple sclerosis. Early imaging investigations in multiple sclerosis (MS) described focal signs. Technological progress now suggests this concept should be revisited as more diffuse anomalies of the central nervous system are described, sometimes involving regions...

Clancy, J.L.uise; Saunders, D.N.; Hird, S.L.; Henderson, M.J.; Ormandy, C.J.; Sutherland, R.L.; Watts, C.K.W., 2003: Defining the function of the mammalian ortholog of Drosophila melanogaster hyperplastic discs gene EDD by gene targeting. Proceedings of the American Association for Cancer Research Annual Meeting 44: 1174, July

Stutzmann, J.M.; Delahaye, C.; Allain, H., 1993: Zopiclone. Data of experimental pharmacology and clinical use. Zopiclone is the first of the cyclopyrrolones, a new class of psychotropic agents which is chemically different from the benzodiazepines (BZD). From an experimental point of view it has qualitatively the pharmacological profile of the tranquilizer...

Klein, D., 1982: MSU studies MDs' unease with patients unlike them. Michigan Medicine 81(18): 232-232

Kemmer, E., 1932: Germany's most popular apple. A questionnaire to which replies were received from some 138 experts throughout the country establishes the quite remarkable ascendancy of Belle de Boskoop in popular favour. In no less than 83 replies it was given first place, against 15 replies...

Nogués, A.; Suñol, M.A.; Barriola, M., 1984: Hydatid renal cyst with characteristic sonographic pattern. A case report. The kidney is a rare localisation of the hydatid cyst even in countries with a high rate of infestation. We report a case of renal hydatid cyst in a five-year-old girl. Conventional radiology did not yield any diagnosis, whereas in this case renal...

Eifert, Virginia S., 1964: Hornet hexagons. Living Mus 26(7): 339-344

Giangregorio, F.; Bertone, A.; Fanigliulo, L.; Comparato, G.; Aragona, G.; Marinone, M.G.; Sbolli, G.; Tansini, P.; Fornari, F., 2009: Predictive value of time-intensity curves obtained with contrast-enhanced ultrasonography (CEUS) in the follow-up of 30 patients with Crohn's disease. Sommario OBIETTIVI: La CEUS è in grado di quantificare accuratamente la microvascolarizzazione della parete intestinale nel Crohn. IPOTESI: L'infiammazione della parete intestinale non è correlata con la quantità di parete vascolarizzata (...

Drewe, J.; Delco, F.; Kissel, T.; Beglinger, C., 2003: Effect of intravenous infusions of thiamine on the disposition kinetics of thiamine and its pyrophosphate. Background: Thiamine supplementation is necessary in patients with thiamine deficiency syndromes. Experimental evidence suggests that tissue uptake and the elimination of thiamine are dose-dependent. Aim: The aim of the present study was to invest...