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Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention

, : Epigenetic mechanisms in anti-cancer actions of bioactive food components–the implications in cancer prevention.

The hallmarks of carcinogenesis are aberrations in gene expression and protein function caused by both genetic and epigenetic modifications. Epigenetics refers to the changes in gene expression programming that alter the phenotype in absence of a change in DNA sequence. Epigenetic modifications, which include amongst others DNA methylation, covalent modifications of histone tails, and regulation by non-coding RNAs, play a significant role in normal development and genome stability. The changes are dynamic and serve as an adaptation mechanism to a wide variety of environmental and social factors including diet. A number of studies provide evidence that some natural bioactive compounds found in food and herbs can modulate gene expression by targeting different elements of the epigenetic machinery. Nutrients that are components of one carbon metabolism such as folate, riboflavin, pyridoxine, cobalamin, choline, betaine, and methionine, affect DNA methylation by regulating levels of S-adenosyl-L-methionine, a methyl group donor, and S-adenosyl-L-homocysteine which is an inhibitor of enzymes catalyzing the DNA methylation reaction. Other natural compounds target histone modifications and levels of non-coding RNAs such as vitamin D that recruits histone acetylases or resveratrol that activates the deacetylase sirtuin and regulates oncogenic and tumour suppressor micro-RNAs. Since epigenetic abnormalities have been shown to be both causative and contributing factors in different health conditions including cancer, natural compounds that are direct or indirect regulators of the epigenome constitute an excellent approach in cancer prevention and potentially in anti-cancer therapy.


DOI: 10.1111/j.1476-5381.2012.02002.x

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