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The Solute Carrier Family 6


, : The Solute Carrier Family 6.

The SLC6 family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.

US$19.90

DOI: 10.1111/j.1476-5381.2012.01975.x


Other references

Warden, S.J.; Fuchs, R.K.; Castillo, A.B.; Turner, C.H., 2005: Does exercise during growth influence osteoporotic fracture risk later in life?. Journal of Musculoskeletal & Neuronal Interactions 5(4): 344-346

Enoch, S., 2005: The Mexico Summit on Health Research 2004: medical community in developing countries has duty to promote healthcare research. Bmj 330(7488): 421-421

Luft, F.C., 2006: The serum- and glucocorticoid-induced kinase in DOCA-salt hypertension. Journal of Molecular Medicine 84(9): 709-711

Szoszkiewicz, R.; Bhushan, B.; Huey, B.D.; Kulik, A.J.; Gremaud, G., 2005: Correlations between adhesion hysteresis and friction at molecular scales. Correlations between adhesion hysteresis and local friction are theoretically and experimentally investigated. The model is based on the classical theory of adhesional friction, contact mechanics, capillary hysteresis, and nanoscale roughness. Adh...

James, P.A.; Anderson, L.; Young, A., 2007: Effectiveness of metaphoric facilitation techniques in a challenge course program on the empowerment of women participants. Research has shown support for the efficacy of differing processing techniques, particularly isomorphic framing. Feminist practitioners contend this methodology disempowers participants. Proponents argue this could result only from improper implem...

Trowbridge, L.; Williams, A.C.; York, P.; Dennis, A.B.; Worthington, V.L., 1997: A comparison of methods for determining powder flow Correlation with tableting performance. Pharmaceutical Research (New York) 14(11 SUPPL ): S415, Nov

Wood, V.E., 1989: Clinodactyly: an unusual presentation. Journal of Hand Surgery 14(4): 449-450

Mathieson, S., 2002: E-novation. Band on the run. Health Service Journal 112(5812): Suppl 16-7

Meibach, R.C., 2003: Comparative effectiveness of antipsychotic drugs. American Journal of Psychiatry 160(3): 589-90; Author Reply 592-3

Nicoli, R.; Bartolini, M.; Rudaz, S.; Andrisano, V.; Veuthey, J-L., 2008: Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies. Two cytochrome P450 (CYP)-based immobilized enzyme reactors (IMERs) were developed to perform automated on-line phase I drug metabolism studies. For this purpose, biotinylated recombinant CYP2D6 or CYP3A4 reconstituted systems were anchored to the...