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Multidimensional optimality of microbial metabolism


, : Multidimensional optimality of microbial metabolism. Science 336(6081): 601-604

Although the network topology of metabolism is well known, understanding the principles that govern the distribution of fluxes through metabolism lags behind. Experimentally, these fluxes can be measured by (13)C-flux analysis, and there has been a long-standing interest in understanding this functional network operation from an evolutionary perspective. On the basis of (13)C-determined fluxes from nine bacteria and multi-objective optimization theory, we show that metabolism operates close to the Pareto-optimal surface of a three-dimensional space defined by competing objectives. Consistent with flux data from evolved Escherichia coli, we propose that flux states evolve under the trade-off between two principles: optimality under one given condition and minimal adjustment between conditions. These principles form the forces by which evolution shapes metabolic fluxes in microorganisms' environmental context.

US$19.90

PMID: 22556256

DOI: 10.1126/science.1216882


Other references

Chant, I.D.; Rose, P.E.; Morris, A.A.G., 1994: Analysis of heat shock protein expression in myeloid leukaemia cells by flow cytometry. British Journal of Haematology 87(SUPPL 1): 166

Doyon D.; Busy F.; Sassoon C.; Laudenbach P.; Couly G., 1982: Steps in radiological exploration of maxillo facial injuries. Radiological examination of maxillofacial injuries, though difficult in patients with multiple lesions, should be rigorously conducted and be as complete as possible, depending on the results of the clinical investigation. Initially, it must inclu...

Berndt, R., 1940: Ueber die Tauchdauer beim Biber, Castor fiber L. Zoologische Garten Leipzig, 12: 195-196

Maekawa, 1995: Electroweak symmetry breaking by vectorlike fermion condensation with small S and T parameters. Physical Review. D, Particles and Fields 52(3): 1684-1692

Reiffers, J., 1974: Pathomimesis. Schweizerische Rundschau für Medizin Praxis 63(29): 87-93

Housley, C., 1979: Orienting the new material manager. Dimensions in Health Service 56(10): 20-20

Choi, S.H.; Lee, S.B.; Kim, H.U., 1997: DNA fingerprinting and physiological characteristics of lactic acid bacteria used to manufacture yogurt. Arbitrarily primed-polymerase chain reaction (AP-PCR) and restriction fragment length polymorphism (RFLP) with digoxigenin-labelled M13 probe were used to identify the strain of lactic acid bacteria used to manufacture yoghurt. The AP-PCR of DNA i...

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