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Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice

, : Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science 336(6081): 604-608

Medical applications of nanotechnology typically focus on drug delivery and biosensors. Here, we combine nanotechnology and bioengineering to demonstrate that nanoparticles can be used to remotely regulate protein production in vivo. We decorated a modified temperature-sensitive channel, TRPV1, with antibody-coated iron oxide nanoparticles that are heated in a low-frequency magnetic field. When local temperature rises, TRPV1 gates calcium to stimulate synthesis and release of bioengineered insulin driven by a Ca(2+)-sensitive promoter. Studying tumor xenografts expressing the bioengineered insulin gene, we show that exposure to radio waves stimulates insulin release from the tumors and lowers blood glucose in mice. We further show that cells can be engineered to synthesize genetically encoded ferritin nanoparticles and inducibly release insulin. These approaches provide a platform for using nanotechnology to activate cells.


PMID: 22556257

DOI: 10.1126/science.1216753

Other references

Trunilina V.A., 1994: Geodynamic position, genesis and criteria for ore content of tin-bearing granitoids from the Yana-Kolyma region. Pages 430-434 1994

Vernejoul, M.-De; Queille, M.; Nordin, R.; Mautalen, C.; Miravet, L., 1979: Action of Solanum malacoxylon on bone histology of vitamin D deficient rats. Vitamin D: basic research and its clinical application: proceedings of the Fourth Workshop on Vitamin D Berlin West Germany February 1979 editors A W Norman et al: 406

Tarr, J.; Botkin, G.; Rice, E.L.; Carpenter, E.; Hart, M., 1980: A broad analysis of fifteen sites in the tall-grass prairie of Oklahoma. Tall-grass prairie stands which varied from 3 to 80 ac were located in 15 counties in Oklahoma. 9 had been hay meadows and the rest were natural climax prairie vegetation. Av. temp. and rainfall/yr and sp. composition are listed for each site. And...

Miura, M.; Sugiura, T.; Aimi, Y.; Yasuda, K.; Ito, S.; Baba, E.; Katsuya, H., 1998: Effects of ulinastatin on PMNL and vascular endthelial injury in patients undergoing open heart surgery with CPB. Activated leukocytes are thought to contribute to respiratory dysfunction, alterations in microvascular permeability, disseminated intravascular coagulation, and thrombosis, all of which can complicate cardiopulmonary bypass (CPB). We have measure...

Andreottola, G.; Foladori, P.; Nardelli, P.; Denicolo, A., 2005: Treatment of winery wastewater in a full-scale fixed bed biofilm reactor. The treatment of winery wastewater was performed at full-scale applying a two-stage fixed bed biofilm reactor (FBBR) system for the discharge in the sewerage. The results of the first year of operation at the full-scale plant are presented. Values...

Stew, B.T.; Fishpool, S.J.C.; Clarke, J.D.; Johnson, P.M., 2014: Can early second-look tympanoplasty reduce the rate of conversion to modified radical mastoidectomy?. Combined approach tympanoplasty (CAT) allows for successful treatment of cholesteatoma with rates of recurrent and residual disease comparable to open mastoid surgery. Early timing of second-look procedures allows easier removal of any recurrent o...

Palacio, A. del; Cuetara, M.S.; Ponton, J., 2003: Invasive aspergillosis. This volume contains 7 articles discussing clinical manifestations and treatment of invasive aspergillosis, and diagnosis of invasive aspergillosis in neutropenic patients, haematologic patients and transplant recipients. The value of galactomanna...

Rahman, M.; Yu, E.; Forman, E.; Roberson-Mailloux, C.; Tung, J.; Tringe, J.; Stroeve, P., 2015: Modified release from lipid bilayer coated mesoporous silica nanoparticles using PEO-PPO-PEO triblock copolymers. Triblock copolymers comprised of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO, or trade name Pluronic) interact with lipid bilayers to increase their permeability. Here we demonstrate a novel application of Pluronic...

Endo, Y., 2007: A historical review of the deployment of European integration and its relevant policy development including economic, monetary, agricultural and rural policies. European integration has moved forward on a step-by-step basis, from Free Trade Area, Customs Union, and Common Market to Economic Union and is entering into the final stage of Complete Economic Union. A historical review of European integration i...

Herbst, G., 1958: A defibrination-rotation method for demonstrating LE cells. American Journal of Medical Technology 24(5): 285-288