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Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood

, : Pilot study: potential transcription markers for adult attention-deficit hyperactivity disorder in whole blood. Attention Deficit and Hyperactivity Disorders 4(2): 77-84

Attention-deficit hyperactivity disorder (ADHD) is a common behavioural disorder that affects not only children and adolescents but also adults; however, diagnosis of adult ADHD is difficult because patients seem to have reduced externalized behaviour. ADHD is a multifactorial disorder in which many genes, all with small effects, are thought to cause the disorder in the presence of unfavourable environmental conditions. Therefore, in this pilot study, we explored the expression profile of a list of previously established candidate genes in peripheral blood samples from adult ADHD subjects (n = 18) and compared these results with those of healthy controls (n = 35). We demonstrate that combining the gene expression levels of dopamine transporter (SLC6A3), dopamine D5 receptor, tryptophan hydroxylase-1, and SNAP25 as predictors in a regression model resulted in sensitivity and specificity of over 8 % (ROC: max R2 = .587, AUC = .917, P < .1, 95 % CI: .9 .985). In conclusion, the combination of these four genes could represent a potential method for estimating risk and could be of diagnostic value for ADHD. Nevertheless, further investigation in a larger independent population including different subtypes of ADHD (inattentive, hyperactive, or combined type) patients is required to obtain more specific sets of biomarkers for each subtype as well as to differentiate between child, adolescent, and adulthood forms.


PMID: 22562805

DOI: 10.1007/s12402-012-0074-6

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Stone, M.M.; Lewin, K.; Fonkalsrud, E.W., 1986: Late obstruction of the lateral ileal reservoir after colectomy and endorectal ileal pullthrough procedures. During a period of eight years, 19 of 83 patients underwent colectomy, mucosal proctectomy and endorectal ileal pull-through procedures with isoperistaltic ileal reservoir for ulcerative colitis or polyposis. These patients had late obstruction of...

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Norman, J.R., 1937: Illustrated Guide to the Fish Gallery (British Museum, Natural History). London

Buecher T.; Krietsch W.K.G., 1987: Hereditary deviations of glycolytic enzyme activities in human blood cells. Enzyme (Basel) 38(SUPPL 1): 4

Hickson, H.E.; Jofeh, A.J.; Bulman, R.A., 1947: Notes on wood preservation, by pressure methods, in Great Britain, New Zealand, Australia, and South Africa, against a background of standardization. The authors describe the present stage of development of wood preservation by pressure methods in Great Britain, New Zealand, Australia, and South Africa, the picture having as a background the process of standardization and the manner in which th...

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Solem, J.H.; Salvesen, S., 1959: Evaluation of adrenocortical function with the help of intramuscular injections of long-acting ACTH. Tidsskrift for den Norske Laegeforening 79: 1285-1291

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