geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis


, : C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Arthritis Research & Therapy 14(3): R140-R140

The complement system is crucial for the development of ANCA-associated vasculitis (AAV). In particular, C5a plays a central role. In this study, plasma and urinary levels of C5a as well as renal C5a receptors (CD88 and C5L2) expression were investigated in patients with AAV. 24 patients with AAV in active phase, 19 patients with AAV in remission phase and 2 patients with lupus nephritis (LN) were included. Plasma and urinary levels of C5a were measured by ELISA. The staining of CD88 and C5L2 in renal specimens was detected by immunohistochemistry. The level of plasma C5a was significantly higher in patients with AAV in active phase than that in patients in remission, that in patients with LN and that in normal controls. The urinary C5a level was significantly higher in patients with AAV in active phase than that in patients in remission and that in normal controls, but not significantly different between patients with active AAV and patients with LN. The mean optical density of CD88 staining in tubulointerstitium was significantly lower in AAV patients than that in normal controls (.52+/-.11 vs.29+/-.42, P=.5). The mean optical density of C5L2 in glomeruli was significantly higher in AAV patients than that in normal controls (.13+/-.27 vs.32+/-.6, P<.1). The mean optical density of CD88 staining closely correlated with initial eGFR (r=.835, P<.1) in AAV patients. Double-labeling immunofluorescence assay suggested that CD88 did not express on neutrophils, monocytes or macrophages, but C5L2 expressed on neutrophils (or monocytes) and macrophages.The elevated plasma and urinary C5a levels indicated complement activation in human AAV. The level of renal CD88 expression could reflect the disease severity of ANCA-associated glomerulonephritis. CD88 expression was down-regulated and C5L2 was up-regulated in ANCA-associated glomerulonephritis.

US$19.90

PMID: 22691190

DOI: 10.1186/ar3873


Other references

Turpin, R.S.; Ozminkowski, R.J.; Sharda, C.E.; Collins, J.J.; Berger, M.L.; Billotti, G.M.; Baase, C.M.; Olson, M.J.; Nicholson, S., 2004: Reliability and validity of the Stanford Presenteeism Scale. This study reports the reliability and validity of the 13-item Stanford Presenteeism Scale (SPS). The SPS differs from similar scales by focusing on knowledge-based and production-based workers. Data were obtained from administrative and medical c...

Stephens F.H., 1968: Impressive silver developments, revival at Great Bear Lake. Describes progress from 1964 in the Echo Bay Mines Ltd, highly successful silver mine at Port Radium. A silver-copper vein being worked contains enough copper to cover transportation cost, and high-grade uranium-silver ore is being stockpiled. Shi...

Sarma, P.S.; Kumari, T.S., 1996: Effect of water stress, varieties and potassium on sorghum in Vertisols. Field experiments were conducted in Vertisols at Rajendranagar, Hyderabad during the post-rainy seasons of 1988/89 and 1989/90 to study the effect of K application on 3 sorghum cultivars grown under water stress conditions. Sorghum was grown witho...

Holland, D.; Jones, D., 1981: Micro-encapsulated feed enhances dietary value of Artemia. Fish farming international 8(4): 17

Anonymous, 2011: Pro-Inflammatory Cytokine Levels in Hyperlipidaemic Patients with Periodontitis After Periodontal Treatment. The aim of this study was to evaluate the effects of periodontal treatment on serum and gingival crevicular fluid (GCF) pro-inflammatory cytokine levels in hyperlipidaemic patients with periodontitis.Materials and Fifty two patients with hyperlipi...

Guillén-Bonilla, A.; Rodríguez-Betancourtt, Vónica-María.; Flores-Martínez, Mín.; Blanco-Alonso, O.; Reyes-Gómez, J.; Gildo-Ortiz, L.; Guillén-Bonilla, Héctor., 2015: Dynamic response of CoSb2O6 trirutile-type oxides in a CO2 atmosphere at low-temperatures. Experimental work on the synthesis of the CoSb2O6 oxide and its CO2 sensing properties is presented here. The oxide was synthesized by a microwave-assisted colloidal method in presence of ethylenediamine after calcination at 600 °C. This CoSb2O6...

Morley, J.E., 2014: Treatment of hypertension in older persons: what is the evidence?. Evidence for treatment of hypertension in older people is limited to placebo-controlled studies that reduced blood pressure in persons over 60 years who had systolic blood pressure >160 mmHg. Generally, physicians measure blood pressure poorly,...

Lowery, D.E.; Geary, T.G.; Kubiak, T.M.; Larsen, M.J., 2003: G protein-coupled receptor-like receptors and modulators thereof. The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of va...

Santee, M.L.; Read, W.G.; Waters, J.W.; Froidevaux, L.; Manney, G.L.; Flower, D.A.; Jarnot, R.F.; Harwood, R.S.; Peckham, G.E., 1995: Interhemispheric Differences in Polar Stratospheric HNO3, H2O, CIO, and O3. Simultaneous global measurements of nitric acid (HNO(3)), water (H(2)O), chlorine monoxide (CIO), and ozone (O(3)) in the stratosphere have been obtained over complete annual cycles in both hemispheres by the Microwave Limb Sounder on the Upper At...

Carter, H.E.; Koob, J.L., 1969: Sphingolipids in bean d leaves phaseolus vulgaris d flax d seed ceramide cerebroside phosphate di ester linkage tri saccharide inositol hex uronic acid hexos amine mannose arabinose galactose. Journal of Lipid Research 10(4): 363-369