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A nem pegilalt liposzomalis doxorubicin Myocet®, mint a szabad doxorubicin kevesbe kardiotoxikus alternatívaja


, : A nem pegilalt liposzomalis doxorubicin Myocet®, mint a szabad doxorubicin kevesbe kardiotoxikus alternatívaja.

Val sz n?leg az antraciklinek tekintend?k az eml?r k valamint az egy b szolid tumorok s az egyes malignus hematol giai k rk pek legakt vabb gy gyszereinek. Sajnos, a d zist l f gg? kardiotoxicit suk van, mely progressz v sz vizom-k rosod shoz vezethet, s korl tozza a beadhat maxim lis kumulat v d zist. Az ttekint? k zlem ny a nem pegil lt liposzom lis doxorubicinre (Myocet ) koncentr l, melyet a szabad doxorubicin ter pi s index nek jav t sa c lj b l alak tottak ki. A doxorubicinnek egy makromolekul ris vektorba (liposz m ba) val foglal sa r v n egy nanor szecske alap gy gyszerhordoz rendszer j n l tre, melynek k vetkezt ben cs kken a gy gyszer megoszl si volumene, cs kken az p sz vetekre gyakorolt toxicit s, ugyanakkor n vekszik a daganatban el rhet? koncentr ci . A leggyakoribb mell khat s a neutropenia, mely a szabad doxorubicinnel szerzett el?zetes tapasztalatoknak felel meg. A rendelkez sre ll bizony t kok szerint a hematol giai toxicit s is enyh bb a konvencion lis doxorubicin mellett szleltekn l. A Myocet monoter pi ban, vagy kombin ci kban hat sos s biztons gos gy gyszer, ritk bb s enyh bb kardi lis mell khat sokkal j r. Magyar Onkol gia 54: 359 367, 21.

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