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Az el?rehaladott vesedaganat kezelesenek ujabb lehet?segei a nemzetkozi ajanlasok tukreben

, : Az el?rehaladott vesedaganat kezelesenek ujabb lehet?segei a nemzetkozi ajanlasok tukreben.

A vil gossejtes veser k kialakul s hoz vezet? molekul ris biol giai elt r sek egyre pontosabb meg rt se utat nyitott a c lzott ter pi k (tirozinkin z-inhibitorok s mTOR-g tl k) kifejleszt s hez. Ezek az j szerek jelentik ma m r az el?rehaladott veser k standard kezel s t. Az j szerek helye az tt tes vesedaganatos betegek kezel s ben randomiz lt klinikai vizsg latokkal d nthet? el. A jelenleg rendelkez sre ll adatok alapj n a j vagy k zepes progn zis betegek els? vonal kezel s nek alapgy gyszere a sunitinib, a pazopanib vagy a bevacizumab+interferon. Szelekt lt betegekn l sorafenib vagy j llapot betegekn l nagy d zis IL-2 is sz ba j n. Rossz progn zis betegek els? vonal kezel se temsirolimusszal t rt nik. M sodvonalban citokinre progredi l betegekn l sorafenib, TKI-ra progredi l betegn l everolimus j n sz ba. Magyar Onkol gia 54: 369 376, 21.


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Agmo, A.; Soria, P., 1999: The duration of the effects of a single administration of dopamine antagonists on ambulatory activity and motor coordination. Pimozide, cis(Z)-flupenthixol, SCH 23390 and sulpiride were administered to male rats. Each subject received a single drug injection, and tests for ambulatory activity and motor coordination were performed 1, 24, 48 and 72 hrs later. All drugs red...