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A D-nap A D-vitamin helye a daganatprevencioban es a kiegeszít? kezelesben

, : A D-nap A D-vitamin helye a daganatprevencioban es a kiegeszít? kezelesben.

A D-vitamin lettani hat sa t bb, mint a kalcium- s csontanyagcsere szab lyoz sa. Szerepe van t bbek k z tt a tumorgenezis g tl s ban, sok daganatf les g eset ben pedig kemoprevent v szer is. Pluripotens, para- s autokrin szteroidhormon, melynek szint zis re az emberi szervezet maga is k pes. Sok epidemiol giai adat t masztja al a D-vitamin daganatellenes hat s t: az egyenl t?t?l t volodva az eml?-, prosztata- s vastagb ldaganatok incidenci ja n?. Ezt k vet?en sejt- s llatk s rletek t masztott k al a D-vitamin sejtprolifer ci t g tl s sejtdifferenci ci t serkent? hat s t. Klinikai vizsg latok legink bb a prosztata- s vastagb ldaganatok eset ben t rt ntek s tal ltak meggy?z? sszef gg st az alacsony D-vitamin-szint s a daganatok el?fordul sa k z tt. In vitro s in vivo is igazolt k, hogy daganatos sejtekben a D-vitamin-kezel s sejtdifferenci ci t, sejtciklusle ll st, ill. apopt zist induk l. A leg jabb eredm nyek szerint sz mos sz vetben lok lisan is van D-vitamin-k pz?d s, mely a malignus fenot pus kialakul s val s a sejtek dedifferenci l d s val egyre cs kken, s?t evvel p rhuzamosan a D-vitamin lebont s rt felel?s 24?-hidroxil z enzim aktivit s nak lok lis n veked se is megfigyelhet?. Mindezen eredm nyek alapj n biztat , imm r klinikai f zis 1 s 2 vizsg latok is rendelkez sre llnak szelekt v, lok lisan hat 24?-hidroxil z-g tl kkal t bb daganatf les g ak r els?vonalbeli kezel sek nt. Jelenleg azonban az egyik legfontosabb feladat haz nk lakoss ga s lyos D-vitamin-hi ny nak felsz mol sa. Magyar Onkol gia 54: 33 314, 21.


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