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The complement system: history, pathways, cascade and inhibitors

, : The complement system: history, pathways, cascade and inhibitors. European Journal of Microbiology & Immunology 2(2): 103-111

Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.


PMID: 24672678

DOI: 10.1556/EuJMI.2.2012.2.2

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