geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis


, : Effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis.

Recent evidence suggests that the effects of certain food additives may be synergistic or additive. Aspartame (ASP) and Monosodium Glutamate (MSG) are ubiquitous food additives with a common moiety: both contain acidic amino acids which can act as neurotransmitters, interacting with NMDA receptors concentrated in areas of the Central Nervous System regulating energy expenditure and conservation. MSG has been shown to promote a neuroendocrine dysfunction when large quantities are administered to mammals during the neonatal period. ASP is a low-calorie dipeptide sweetener found in a wide variety of diet beverages and foods. However, recent reports suggest that ASP may promote weight gain and hyperglycemia in a zebrafish nutritional model. We investigated the effects of ASP, MSG or a combination of both on glucose and insulin homeostasis, weight change and adiposity, in C57BL/6 J mice chronically exposed to these food additives commencing in-utero, compared to an additive-free diet. Pearson correlation analysis was used to investigate the associations between body characteristics and variables in glucose and insulin homeostasis. ASP alone (5 mg/Kgbw/day) caused an increase in fasting blood glucose of 1.6-fold, together with reduced insulin sensitivity during an Insulin Tolerance Test (I) P < .5. Conversely MSG alone decreased blood triglyceride and total cholesterol (T-CHOL) levels. The combination of MSG (12 mg/Kgbw/day) and ASP elevated body weight, and caused a further increase in fasting blood glucose of 2.3-fold compared to Controls (prediabetic levels); together with evidence of insulin resistance during the I (P < .5). T-CHOL levels were reduced in both ASP-containing diets in both genders. Further analysis showed a strong correlation between body weight at 6 weeks, and body weight and fasting blood glucose levels at 17 weeks, suggesting that early body weight may be a predictor of glucose homeostasis in later life. Aspartame exposure may promote hyperglycemia and insulin intolerance. MSG may interact with aspartame to further impair glucose homeostasis. This is the first study to ascertain the hyperglycemic effects of chronic exposure to a combination of these commonly consumed food additives; however these observations are limited to a C57BL/6 J mouse model. Caution should be applied in extrapolating these findings to other species.

US$29.90


Other references

Botchkarev, V.A.; Sharov, A.A., 2004: BMP signaling in the control of skin development and hair follicle growth. Bone morphogenetic proteins (BMPs), their antagonists, and BMP receptors are involved in controlling a large number of biological functions including cell proliferation, differentiation, cell fate decision, and apoptosis in many different types of...

Hoshitani, Y.; E.A., 2003: Treatment for epistaxis in patients with Osler's Disease: Scraping nasal mucosa with a curette. Intranasal dermoplasty, laser photocoagulation, and the administration of estorogen have been used to control epistaxis associated with Osler's disease. We treated two patients who had severe epistaxis due to Osler's disease with scrapin...

Hadfield, M.G.; David, R.B.; Rosenblum, W.I., 1972: Coiled nucleocapsid configuration in subacute sclerosing pancencephalitis (SSPE). Acta Neuropathologica 21(4): 263-271

Cheney, D.; Seyfarth, R.; Fischer, J.; Beehner, J.; Bergman, T.; Johnson, S.; Kitchen, D.; Palombit, R.; Rendall, D.; Silk, J., 2004: Factors affecting reproduction and mortality among baboons in the Okavango Delta, Botswana. We present results of a 10-year study of free-ranging gray-footed chacma baboons (Papio ursinus griseipes) in the Okavango Delta of Botswana. The majority of deaths among adult females and juveniles were due to predation, while infants were more l...

Kindvall, O.; Bergman, K.-Olof., 2004: Woodland brown butterfly (Lopinga achine) in Sweden: viability in a dynamic landscape maintained by grazing. Unknown

Koopal, C.G.J.; Nolte, R.J.M., 1994: Highly stable first-generation biosensor for glucose utilizing latex particles as the enzyme-immobilizing matrix. The ability of polystyrene latex beads to immobilize glucose oxidase was applied to construct a stable biosensor for glucose. This biosensor measures glucose by detecting the hydrogen peroxide produced by the enzyme. The biosensor performance was...

Bikerman, J.J., 1935: The concentration changes at membranes and the electroosmotic membrane potentials. From the theory of the diffuse double layer expressions are derived for both the electrolyte transport and the potential differences at membranes through which an electroosmotic current is driven, These expressions are discussed and compared with...

Nukatsuka, M.; Yoshimura, Y.; Nishida, M.; Kawada, J., 1990: Importance of the concentration of ATP in rat pancreatic beta cells in the mechanism of streptozotocin-induced cytotoxicity. The effects of streptozotocin (STZ) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on monolayer cultures of rat pancreatic beta cells were compared. The intracellular NAD concentration was markedly decreased by both 2 mmol STZ/l and 13.6 mum...

Pack, S., 1980: Nursing care of the cesarean patient. Journal of Practical Nursing 30(9): 22-4, 38-9

Taylor, D.A.; Wiese, S.; Faison, E.P.; Yarbrough, G.G., 1983: Pharmacological characterization of purinergic receptors in the rat vas deferens. Using the isolated rat vas deferens, we have confirmed the existence of P1 purinergic receptors whose activation results in an inhibition of the neurogenic twitch of the vas deferens. The observed order of potency for agonists (adenosine ethyl car...