geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Surgery after treatment with imatinib and/or sunitinib in patients with metastasized gastrointestinal stromal tumours Is it worthwhile?


, : Surgery after treatment with imatinib and/or sunitinib in patients with metastasized gastrointestinal stromal tumours Is it worthwhile?.

Standard treatment for metastatic gastrointestinal stromal tumors (GISTs) is systemic therapy with imatinib. Surgery is performed to remove metastatic lesions to induce long-term remission or even curation. In other patients, surgery is performed to remove (focal) progressive or symptomatic lesions. The impact and long-term results of surgery after systemic therapy have not been clearly defined. Between September 21 and May 21, all patients with metastatic GIST who underwent surgery for metastatic GIST after systemic therapy (that is, imatinib and sunitinib) at four Dutch specialized institutions were included. Primary end-points were progression-free survival (PFS) and overall survival (OS). All 55 patients underwent surgery after treatment with systemic therapy. At the last follow-up, tumor recurrence or progression was noted after surgery in 48% of the patients who responded on systemic therapy, and in 85% of the patients who were treated while having progressive disease. Median PFS and OS were not reached in the group of responders. In the non-responders group PFS and OS were median 4 and 25 months, respectively. Response on systemic therapy and a surgical complete resection were significantly correlated to PFS and OS. Surgery may play a role in responding patients. In patients with progressive disease, the role of surgery is more difficult to distinguish in this retrospective analysis since PFS is short. Which patients benefit and whether this improves long-term outcome should be established in a multicentric randomized trial.

US$29.90


Other references

Bussel, A.; Sitthy, X.; Reviron, J., 1982: Technological aspects and complications of plasma exchange. Revue Francaise de Transfusion et Immuno-Hematologie 25(5): 547-576

Chevski , A.A., 1929: Diseases of cotton. A comprehensive review of Russian and foreign literature dealing with the diseases of cotton is given. Results of phytopathological surveys carried out under the supervision of the author in 1928-29 in Azerbaidzhan and Central Asia, and in the new...

Kleeva O.B.; Pavlova I.P.; Padalkin V.P., 1985: Elisa enzyme linked immunosorbent assay as a test system for the determination of antibodies to the production strains of fodder yeast. ELISA as a specific and highly sensitive test system was used for the examination of large groups of workers employed in the production of fodder protein to detect antibodies to the production strains of fodder yeast. The results yielded by ELISA...

David D.; Lang R.M.; Neumann A.; Borow K.M.; Akselrod S.; Mor Avi V., 1990: Parasympathetically modulated antiarrhythmic action of lidocaine in atrial fibrillation. Clinical experience has shown that the antiarrhythmic effect of lidocaine on atrial arrhythmias, and specifically for the conversion of atrial fibrillation to normal sinus rhythm, is minimal. This study summarizes our experience in 30 dogs in whic...

Said, J., 2003: Transformation to aggressive B-cell lymphoma: morphology, immunophenotype, and molecular characteristics. Many indolent lymphomas are destined for eventual transformation to aggressive B-cell lymphomas, an event with significant impact on therapy and outcome. Specific morphologic patterns of transformation are described for common subtypes of low-grad...

Matheson A.F., 1956: The Saint John del Rey Mining Company, Limited, Minas Geraes, Brazil; history, geology, and mineral resources. Outlines the geologic setting of gold-bearing sulfide ores, iron (itabirite) and secondary manganese deposits, and other occurrences of metallic and nonmetallic minerals in Precambrian rocks of the Nova Lima and Minas series in a mining concession...

Yamamoto, S.; Iwao, Y., 2000: Injection of IP3 induces a transient increase of intracellular Ca2+ levels in the newt eggs. Zoological Science (Tokyo) 17(Supplement): 64, December

Bernasconi, R., 1997: Conchological variability of Heleobia (Semisalsa) dobrogica (Mollusca Prosobranchia Hydrobiidae Cochliopinae) from subterranean waters of Mangalia, Dobrogea, Romania. Unknown

Squeo, F., A.; Olivares, N.; Valenzuela, A.; Pollastri, A.; Aguirre, E.; Aravena, R.; Jorquera, C.; Ehleringer, J., R., 1999: Fuentes de agua utilizadas por las plantas deserticas y su importancia en planes de manejo y restauracion ecologica. Water is the most important factor that affects primary production and plant structure in arid ecosystems. Because desert plant species can present different mechanisms to use water from different supplies in the substratum (superficial and profou...

Arnold, F.J.L.; Hofmann, F.; Bengtson, C.Peter.; Wittmann, M.; Vanhoutte, P.; Bading, H., 2004: Microelectrode array recordings of cultured hippocampal networks reveal a simple model for transcription and protein synthesis-dependent plasticity. A simplified cell culture system was developed to study neuronal plasticity. As changes in synaptic strength may alter network activity patterns, we grew hippocampal neurones on a microelectrode array (MEA) and monitored their collective behaviour...