+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease

, : The clinicopathological features of colorectal mucinous adenocarcinoma and a therapeutic strategy for the disease. World Journal of Surgical Oncology 10: 109-109

The guidelines established by the National Comprehensive Cancer Network do not describe mucinous histology as a clinical factor that should influence the therapeutic algorithm. However, previous studies show conflicting results regarding the prognosis of colorectal mucinous adenocarcinoma. In this study, we described the clinicopathological features of mucinous adenocarcinoma in Japan, to identify optimal therapeutic strategies. 144 patients with mucinous and 2673 with non-mucinous adenocarcinomas who underwent primary resection in two major centers in Yokohama, Japan were retrospectively evaluated for clinicopathological features and treatment factors. A multivariate analysis for overall survival followed by the comparison of overall survival using Cox proportional hazard model were performed. Patients with mucinous adenocarcinoma had larger primary lesions, higher preoperative CEA levels, a deeper depth of invasion, higher rates of nodal and distant metastasis, and more metastatic sites. A multivariate analysis for overall survival revealed a mucinous histology to be an independent prognostic factor. In the subgroup analysis stratified by stage, Patients diagnosed as StageIII and IV disease had a worse survival in mucinous adenocarcinoma than non-mucinous, while survival did not differ significantly in patients diagnosed as Stage-IIdisease. In StageIII, local recurrence in rectal cases and peritoneal dissemination were more frequently observed in patients with a mucinous histology. Our study indentified that mucinous adenocarcinoma was associated with a worse survival compared with non-mucinous in patients with StageIII and IV disease. In rectal StageIII disease with mucinous histology, additional therapy to control local recurrence followed by surgical resection may be a strategical alternative. Further molecular investigations considering genetic features of mucinous histology will lead to drug development and better management of peritoneal metastasis.


PMID: 22703761

DOI: 10.1186/1477-7819-10-109

Other references

Casado Llompart, J.R.; Rodriguez Gonzalez, M., 1987: Justification for occlusal adjustment in complete denture. Revista de Actualidad Estomatologica Espanola 47(361): 41-2, 45-7

Robinson, R., 1978: A time series and comparative study of mutant gene frequencies of cat populations of Southern England. Carnivore Genetics Newsletter: 36: 211-219

Mitidieri, A.; Claver, F.K.; Bianchini, P.R., 1974: Evaluation of early harvesting, foliage desiccation and substances stimulating sprouting in seed potato used for second-crop planting in the Rosario area. In a study designed to assess ways of producing suitable seed for the second growing season of the year, treatment with rindite to promote sprouting was more successful than treatment with GA for the varieties Huinkul and White Rose, but it was of...

Watanabe, M.; Iwai, K.; Shibata, S.; Takahashi, K.; Narui, T.; Tashiro, T., 1986: Purification and characterization of mouse alpha 1-acid glycoprotein and its possible role in antitumor activity in some lichen polysaccharides. Anti-tumour polysaccharides isolated from the lichens Gyrophora [Umbilicaria] esculenta, Cetraria islandica and C. richardsonii increased the serum level of alpha 1-acid glycoproteins in mice.

Ferraz, E.S.B., 1976: Sensitivity of the dual gamma energy method for soil density and water content determinations. The principle of the method, the most suitable gamma radiation sources for maximum sensitivity, and the effect of the soil attenuation coefficient on results are discussed with reference to experimental data.

Csuka J.; Petrovsky E., 1970: Serum esterase polymorphism in chickens. Braend, M (President) Xith European Conference on Animal Blood Groups And Biochemical Polymorphism Warsaw, July 2nd-6th, 1968 Xvi+607p Illus Dr W Junk N V : Hague, The Netherlands 433-437

Pomeroy, R.S.; Balamurugan, K.; Wong, H.; Duncan, G., 2015: High-resolution melt analysis of the minisatellite D1S80: a potential forensic screening tool. High-resolution melt (HRM) analysis of the VNTR region of the human D1S80 locus, a 16-bp repeat minisatellite from approximately 400 to over 700 bp in length, was investigated. A Qiagen Rotor-Gene Q using the Type-it PCR HRM kit was used to acquir...

Audinot, V.; Lahaye, C.; Suply, T.; Rovere Jovene, C.; Rodriguez, M.; Nicolas, J.P.ul; Beauverger, P.; Cardinaud, B.; Galizzi, J.P.erre; Fauchere, J.L.c; Nahon, J.L.uis; Boutin, J.A., 2002: SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. Melanin-concentrating hormone (MCH) is a cyclic peptide, mainly involved in the regulation of skin pigmentation in teleosts and feeding behavior in mammals. The human keratinocyte SVK14 cell line has been previously shown to express binding sites...

Raychaudhuri, Siba P., 2001: Molecular and cellular events in the pathogenesis of psoriasis. Skin Pharmacology & Applied Skin Physiology 14(3): 160, May-June

Gao, N.; Jennings, P.; Guo, Y.; Yuan, D., 2011: Regulatory role of natural killer (NK) cells on antibody responses to Brucella abortus. Our previous studies have indicated an important regulatory role for natural killer (NK) cells, a major constituent of the innate immune system in modulating antigen-specific responses. Herein, we have investigated the possible participation of th...