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Effects of leptin replacement alone and with exendin-4 on food intake and weight regain in weight-reduced diet-induced obese rats


, : Effects of leptin replacement alone and with exendin-4 on food intake and weight regain in weight-reduced diet-induced obese rats. American Journal of Physiology. Endocrinology and Metabolism 302(12): E1576-E1585

Weight loss in obese humans produces a relative leptin deficiency, which is postulated to activate potent orexigenic and energy conservation mechanisms to restrict weight loss and promote weight regain. Here we determined whether leptin replacement alone or with GLP-1 receptor agonist exendin-4 attenuates weight regain or promotes greater weight loss in weight-reduced diet-induced obese (DIO) rats. Forty percent restriction in daily intake of a high-fat diet in DIO rats for 4 wk reduced body weight by 12%, body fat by 29%, and plasma leptin by 67% and normalized leptin sensitivity. When food restriction ended, body weight, body fat, and plasma leptin increased rapidly. Daily administration of leptin [3-h intraperitoneal (ip) infusions (4 nmol·kg–1·h–1)] at onset and end of dark period for 3 wk did not attenuate hyperphagia and weight regain, nor did it affect mean daily meal sizes or meal numbers. Exendin-4 (5 pmol·kg–1·h–1) infusions during the same intervals prevented postrestriction hyperphagia and weight regain by normalizing meal size. Coadministration of leptin and exendin-4 did not reduce body weight more than exendin-4 alone. Instead, leptin began to attenuate the inhibitory effects of exendin-4 on food intake, meal size, and weight regain by the end of the second week of administration. Plasma leptin in rats receiving leptin was sevenfold greater than in rats receiving vehicle and 17-fold greater than in rats receiving exendin-4. Together, these results do not support the hypothesis that leptin replacement alone or with exendin-4 attenuates weight regain or promotes greater weight loss in weight-reduced DIO rats.

US$19.90

PMID: 22510712

DOI: 10.1152/ajpendo.00058.2012


Other references

Locksley, R.M.; Heinzel, F.P.; Shepard, H.M.; Agosti, J.; Eessalu, T.E.; Aggarwal, B.B.; Harlan, J.M., 1987: Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells. The capacity of the tumor necrosis factors, TNF-.alpha. and TNF-.beta., products of activated macrophages and lymphocytes, respectively, to stimulate interleukin I (IL-1) release from endothelial cells derived from human umbilical veins was examin...

Sorensen, P., 1999: Organic egg production. Supplement to theme meeting. Since the first conference on organic egg production, held in Denmark in 1995, a 3-year research project has addressed the list of problems outlined at that time. The topics covered in this supplement include the influence of rearing conditions; t...

Yoshioka, S.; Ochsner, S.; Russell, D.L.; Ujioka, T.; Fujii, S.; Richards, J.S.; Espey, L.L., 2000: Expression of tumor necrosis factor-stimulated gene-6 in the rat ovary in response to an ovulatory dose of gonadotropin. Current evidence supports the hypothesis that the biochemical events of mammalian ovulation are analogous to an acute inflammatory reaction. This study reveals that tumour necrosis factor-stimulated gene-6 (TSG-6), which encodes a member of the su...

Ragan, C.I.; Hinkle, P.C., 1975: Ion transport and respiratory control in vesicles formed from reduced nicotinamide adenine dinucleotide coenzyme Q reductase and phospholipids. NADH-coenzyme Q reductase from bovine heart mitochondria (complex I) was incorporated into phospholipid vesicles by the cholate dialysis procedure. Mixtures of purified phosphatidylcholine and phosphatidylethanolamine were required. Oxidation of N...

Stocker, S.D.; Smith, C.A.; Kimbrough, C.M.; Stricker, E.M.; Sved, A.F., 2003: Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats. Increased dietary salt intake was used as a nonpharmacological tool to blunt hypotension-induced increases in plasma renin activity (PRA) in order to evaluate the contribution of the reninangiotensin system (RAS) to hypotension-induced thirst. Rat...

Kosel K.C.; Wilkinson J.M.; Jew J.; Itaya S.K.; Beckwith K.; Williams T.H., 1979: Enzyme therapy and spinal cord regeneration a fluorescence microscopic evaluation. Enhanced spinal cord regeneration and return of function has been claimed to follow enzyme therapy. The effects of mucolytic and proteolytic enzymes on central catecholaminergic fibers after spinal cord transection were investigated. Transections...

Leonova, Tg, 1979: Spelling of two specific epithets of two species of Artemisia L., Artemisia santonica L. and Artemisia Willd. (Asteraceae). Botanicheskii zhurnal Akademiia nauk SSSR Vsesoiuznoe botanicheskoe obshchestvo 64(3): 434

Li, Y.; Atkin, G.M.; Morales, M.M.; Liu, L.Qian.; Tong, M.; Duncan, R.Keith., 2010: Developmental expression of BK channels in chick cochlear hair cells. Cochlear hair cells are high-frequency sensory receptors. At the onset of hearing, hair cells acquire fast, calcium-activated potassium (BK) currents, turning immature spiking cells into functional receptors. In non-mammalian vertebrates, the numb...

Ferguson, M.; McCann, I.; Manners, G., 1998: Less water, more grazing. Some 182 accessions of 37 species were collected from the Arabian Peninsula and local farmers and herders were asked to rank these in order of preference to livestock. A list of priority species was established, including 10 grass species with pot...

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