geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice


, : Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology 302(12): G1397-G1404

Hepcidin is a hepatocellular hormone that inhibits the release of iron from certain cell populations, including enterocytes and reticuloendothelial cells. The regulation of hepcidin (HAMP) gene expression by iron status is mediated in part by the signaling molecule bone morphogenetic protein 6 (BMP6). We took advantage of the low iron status of juvenile mice to characterize the regulation of Bmp6 and Hamp1 expression by iron administered in three forms: 1) ferri-transferrin (Fe-Tf), 2) ferric ammonium citrate (FAC), and 3) liver ferritin. Each of these forms of iron enters cells by distinct mechanisms and chemical forms. Iron was parenterally administered to 10-day-old mice, and hepatic expression of Bmp6 and Hamp1 mRNAs was measured 6 h later. We observed that hepatic Bmp6 expression increased in response to ferritin but was unchanged by Fe-Tf or FAC. Hepatic Hamp1 expression likewise increased in response to ferritin and Fe-Tf but was decreased by FAC. Exogenous ferritin increased Bmp6 and Hamp1 expression in older mice as well. Removing iron from ferritin markedly decreased its effect on Bmp6 expression. Exogenously administered ferritin and the derived iron localized in the liver primarily to sinusoidal lining cells. Moreover, expression of Bmp6 mRNA in isolated adult rodent liver cells was much higher in sinusoidal lining cells than hepatocytes (endothelial >> stellate > Kupffer). We conclude that exogenous iron-containing ferritin upregulates hepatic Bmp6 expression, and we speculate that liver ferritin contributes to regulation of Bmp6 and, thus, Hamp1 genes.

US$19.90

PMID: 22517766

DOI: 10.1152/ajpgi.00020.2012


Other references

Hoffmann, W.E., 1933: The Life-history of a Second Species of Laccotrephes (Hemiptera, Nepidae). An account is given of observations on the bionomics of Laccotrephes sp., which, like L. kohlii, Ferrari, has been observed in South China attacking a variety of aquatic insects, particularly mosquito larvae. All stages are described, and the tech...

Ingram, T.A.; Peters, D.D., 1983: Evaluation of the effects of carbon dioxide used as a pulpal test. Part 2. In vivo effect on canine enamel and pulpal tissues. Journal of Endodontics 9(7): 296-303

Vandresse, J.H.; Palmers, Y.; Dethier, J.; Rousseau, A.; de Saint Hubert, E.; Cornelis, G., 1976: Study of endocranial calcification by computerized encephalotomography. Journal Belge de Radiologie 59(3): 239-251

Haberle R.M.; Montmessin F.; Kahre M.A.; Schaeffer J., 2007: The role of the north residual cap in the present Mars water cycle. LPI Contribution Pages (Abstract 3161

Barthoux J., 1933: Le Siwalik et les roches volcaniques recentes en Afghanistan. Describes the occurrence and character of Siwalik and recent volcanic rocks in Afghanistan.

Grega, T.; Najgebauer, D.; Sady, M.; Tomasik, P., 2004: Polymeric complexes from casein and starch phosphate: Characteristics and enzyme susceptibility. Novel biodegradable materials were prepared from potato starch enriched in phosphato moieties (DS 0.018 and 0.033) and casein in defatted milk. The components were blended in proportions providing starch: casein ratios of 2:1, 1:1, and 1:2 and wer...

Gill Edmund D., 1953: Relationship of the Australasian and north African lower Devonian faunas. "In lower Devonian time there was a close marine faunal connection between the Australasian area and the north African- European area along the Tethys seaway. There was a less successful connection with the North American area, probably by a...

Khouri, I.F.; Keating, M.J., 1998: High-dose chemotherapy for chronic lymphocytic leukemia: eligibility, timing, and benefit?. Annals of Oncology 9(2): 131-132

Fache, F.; Valot, F.; Milenkovic, A.; Lemaire, M., 1996: Catalytic reductive N-alkylation of anilines. Application to the synthesis of N-aryl aminoacid precursors. Different anilines have been monoalkylated by reductive alkylation using ketones and alpha-ketoesters as alkylating agents with good isolated yields. This provided access to aminoacid derivatives. Diastereoselective experiments were also performed...

Mama, K.R.; Steffey, E.P.; Pascoe, P.J., 1996: Evaluation of propofol for general anesthesia in premedicated horses. Objective: To evaluate selected hemodynamic, respiratory, and behavioral responses to propofol in horses premedicated with xylazine or detomidine. Design: Xylazine (0.5 and 1.0 mg/kg of body weight) was administered IV on different days to each of...