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Differential impact of short periods of rapid atrial pacing on left and right atrial mechanical function

, : Differential impact of short periods of rapid atrial pacing on left and right atrial mechanical function. American Journal of Physiology. Heart and Circulatory Physiology 302(12): H2583-H2591

Current techniques to describe atrial function are limited by their load dependency and hence do not accurately reflect intrinsic mechanical properties. To assess the impact of atrial fibrillation on atrial function, combined pressure-volume relationships (PVR) measured by conductance catheters were used to evaluate the right (RA) and left (LA) atrium in 12 isoflurane-anesthetized pigs. Biatrial PVR were recorded over a wide range of volumes during transient caval occlusion at baseline sinus rhythm (SR), after onset of rapid atrial pacing (RAP), after 1 h of RAP, after conversion to SR, and after 1 h of recovery. Cardiac output decreased by 16% (P = 0.008) with onset of RAP. Mean LA and RA pressures increased by 21 and 40% (P < 0.001), respectively, and remained elevated during the entire recovery period. RA reservoir function increased from 51 to 58% and significantly dropped to 43% after resumption of SR (P = 0.017). Immediately after RAP, a right shift of LA end-systolic PVR-intercept for end-systolic volume required to generate an atrial end-systolic pressure of 10 mmHg (24.4 ± 4.9 to 28.1 ± 5.2 ml, P = 0.005) indicated impaired contractility compared with baseline. Active LA emptying fraction dropped from 17.6 ± 7.5 to 11.7 ± 3.7% (P < 0.001), LA stroke volume and ΔP/Δt(max)/P declined by 22% (P = 0.038 and 0.026, respectively), while there was only a trend to impaired RA systolic function. Stiffness quantified by the ratio of pressure to volume at end-diastole was increased immediately after RAP only in the RA (P = 0.020), but end-diastolic PVR shifted rightward in both atria (P = 0.011 LA, P = 0.045 RA). These data suggest that even short periods of RAP have a differential impact on RA and LA function, which was sustained for 1 h after conversion to SR.


PMID: 22505644

DOI: 10.1152/ajpheart.01170.2011

Other references

Luttinger, D.; Durivage, M.E., 1986: Alpha 2-adrenergic antagonists effect on amphetamine-induced behaviors. The effects of alpha 2-adrenergic antagonists on amphetamine-induced locomotion and stereotypy were studied in mice. Six alpha 2-antagonists (i.e., yohimbine, rauwolscine, piperoxan, tolazoline, RX781094, and RS21361) selectively attenuated amphet...

Wils, E., 1990: Conus proximus cebuensis a new subspecies from the Philippines. Gloria Maris, 292: 25-27

Tobin, D.J.; Fenton, D.A.; Kendall, M.D., 1990: Ultrastructural study of exclamation-mark hair shafts in alopecia areata. The prime diagnostic feature of acute alopecia areata is the presence of exclamation mark hairs. These characteristic hairs fracture at their distal end and taper proximally towards the scalp, giving them the appearance of an exclamation mark. Hai...

Zymon, M.; Strzetelski, J., 2007: Dietary value and sensory quality of calf meat depending on different n-3 PUFA sources in the diet. The aim of the study was to determine the effect of different n-3 PUFA sources in a calf diet on the health value and sensory quality of veal. A total of 30 bulls were assigned to 3 groups and fed a milk replacer (7-56 days) and concentrates (7-90...

Berkhout A.J.; Giling Erwin J.M., 1993: On the relationship between reflection imaging and transmission tomography. SEG Annual Meeting Expanded Technical Program Abstracts with Biographies 63: 61-64

H.O.amoto; S.M.zusaki; D.Y.shida; T.M.tsumoto; A.A.iyama; Y.F.kuhara, 1978: Enhancing effect of sucrose pyrolysate on mutagenicity in salmonella typhimurium. Mutation Research/Environmental Mutagenesis and Related Subjects 54(2): 251-0

Westernhagen, HV.; Dethlefsen, V., 1983: North Sea oxygen deficiency 1982 and its effects on the bottom fauna. Ambio, 125: 264-266

Cucci, C.E., 1951: The organization of medical studies in Great Britain. Minerva Medica 42(58-59): Varia, 206-8

Popkova, A.M.; Tolchkov, E.V.; Rasheva, V.I.; Kogan, G.L.; Gvozdev, V.A., 2004: The heterochromatic ABO locus may overlap with the region containing amplified mobile elements and Stellate genes on the X chromosome of Drosophila melanogaster. A loss of certain heterochromatic regions (ABO loci) of various chromosomes dramatically distorts the early embryo development in the progeny of females mutant for the abnormal oocyte (abo) gene, which is located in euchromatin of chromosome 2. On...

Coskun, A.A., 1998: Social-cultural problems of forest villages in Saray. Forest villagers in Turkey have a lower standard of living than non-forest villagers. In these circumstances, increasing the standard of living by creating other sources of income for forest villagers would be a positive step towards increasing fo...