+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Olfactory ferric and ferrous iron absorption in iron-deficient rats

, : Olfactory ferric and ferrous iron absorption in iron-deficient rats. American Journal of Physiology. Lung Cellular and Molecular Physiology 302(12): L1280-6

The absorption of metals from the nasal cavity to the blood and the brain initiates an important route of occupational exposures leading to health risks. Divalent metal transporter-1 (DMT1) plays a significant role in the absorption of intranasally instilled manganese, but whether iron uptake would be mediated by the same pathway is unknown. In iron-deficient rats, blood 59Fe levels after intranasal administration of the radioisotope in the ferrous form were significantly higher than those observed for iron-sufficient control rats. Similar results were obtained when ferric iron was instilled intranasally, and blood levels of 59Fe were even greater in the iron-deficient rats compared with the amount of ferrous iron absorbed. Experiments with Belgrade (b/b) rats showed that DMT1 deficiency limited ferric iron uptake from the nasal cavity to the blood compared with +/b controls matched for iron deficiency. These results indicate that olfactory uptake of ferric iron by iron-deficient rats involves DMTWestern blot experiments confirmed that DMT1 levels are significantly higher in iron-deficient rats compared with iron-sufficient controls in olfactory tissue. Thus the molecular mechanism of olfactory iron absorption is regulated by body iron status and involves DMT1.


PMID: 22492739

DOI: 10.1152/ajplung.00004.2012

Other references

Anonymous, 1974: Gastroesophageal reflux. A panel by correspondence. Archives of Surgery 108(1): 16-23

Clark, J.Tertius, 1931: The bearing of tropical experience on the views of the pathogenesis of rheumatic fever. The rarity of rheumatic fever and of Rattus norvegicus in the tropics, together with the greater incidence of the disease among the poor and careless and in industrial centers, than among the rich and the neat and in the country, leads the author...

Wang, Z.F.; Chen, L.; Liu, F., 2014: Tuning topological edge states of Bi(111) bilayer film by edge adsorption. Based on first-principles and tight-binding calculations, we report that the topological edge states of zigzag Bi(111) nanoribbon can be significantly tuned by H edge adsorption. The Fermi velocity is increased by 1 order of magnitude, as the Dira...

Yamamoto, E.; Kogawa, D.; Tokura, S.; Hayashi, K., 2007: Biomechanical response of collagen fascicles to restressing after stress deprivation during culture. In vitro tissue culture experiments were performed to study the biornechanical response of collagen fascicles to restressing after exposure to non-loaded condition. Collagen fascicles of approximately 300 mu m in diameter were aseptically dissect...

Zhang, L.B.n; Chen, Z.Q.ang; Zhang, Y., 2004: Sequential folding slows the formation of the P3-P7 core of the Candida ribozyme. Acta Biochimica et Biophysica Sinica 36(2): 148, February

He, W.; Liang, Z.; Wu, Y.; Shi, C.; Jia, Z.; Zhou, W.; Li, Y., 2002: Immunocontraceptive effect of a synthetic chimeric peptide of sperm. To investigate the immunocontraceptive ability of a new synthetic chimeric peptide with 35 amino acid residues. A chimeric peptide with 35 amino acid residues was synthesized based on the amino acid sequence of SP17, a protein specific to murine t...

Gant, L.; Heath, K.M.; Ejikeme, G.Goziem., 2009: Early motherhood, high mortality, and HIV/AIDS rates in Sub-Saharan Africa. Despite billions of dollars devoted to HIV/AIDS prevention since 1990, rates of infection continue to climb worldwide, primarily through heterosexual contact, and Sub-Saharan Africa is the worst case scenario (UNAIDS, 2004). Traditional interventi...

Hayward, M., 2006: Influenza pandemic statistics provide wake-up call to healthcare workers. Nursing Standard 1987) 21(11): 12-12

Šutalo, S.; Ruetten, M.; Hartnack, S.; Reusch, C.E.; Kook, P.H., 2016: The effect of orally administered ranitidine and once-daily or twice-daily orally administered omeprazole on intragastric pH in cats. Gastric acid suppressants frequently are used in cats with acid-related gastric disorders. However, it is not known if these drugs effectively increase intragastric pH in cats. To examine the effects of PO administered ranitidine and omeprazole on...

D'Atri, S.; Graziani, G.; Lacal, P.M.; Nisticò, V.; Gilberti, S.; Faraoni, I.; Watson, A.J.; Bonmassar, E.; Margison, G.P., 2000: Attenuation of O(6)-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in jurkat cells. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is important in cellular resistance to certain alkylating antitumor agents such as the methylating drug temozolomide (TMZ). To provide a more rational basis for clinical combin...