+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis

, : Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. American Journal of Physiology. Renal Physiology 302(12): F1529-F1536

The complement cascade is an important part of the innate immune system, but pathological activation of this system causes tissue injury in several autoimmune and inflammatory diseases, including immune complex glomerulonephritis. We examined whether mice with targeted deletion of the gene for factor B (fB–/– mice) and selective deficiency in the alternative pathway of complement are protected from injury in the nephrotoxic serum (NTS) nephritis model of antibody-mediated glomerulonephritis. When the acute affects of the anti-glomerular basement membrane antibody were assessed, fB–/– mice developed a degree of injury similar to wild-type controls. If the mice were presensitized with sheep IgG or if the mice were followed for 5 mo postinjection, however, the fB–/– mice developed milder injury than wild-type mice. The immune response of fB–/– mice exposed to sheep IgG was similar to that of wild-type mice, but the fB–/– mice had less glomerular C3 deposition and lower levels of albuminuria. These results demonstrate that fB–/– mice are not significantly protected from acute heterologous injury in NTS nephritis but are protected from autologous injury in response to a planted glomerular antigen. Thus, although the glomerulus is resistant to antibody-initiated, alternative pathway-mediated injury, inhibition of this complement pathway may be beneficial in chronic immune complex-mediated diseases.


PMID: 22492944

DOI: 10.1152/ajprenal.00422.2011

Other references

Kottner, J.; Surber, C., 2016: Skin care in nursing: A critical discussion of nursing practice and research. Skin (self-)care is part of human life from birth until death. Today many different skin care practices, preferences, traditions and routines exist in parallel. In addition, preventive and therapeutic skin care is delivered in nursing and healthca...

Harpuder, K., 1949: Physical medicine in peripheral vascular diseases. Medical Clinics of North America 33: 347-358

Ou, X.; Hong, F.; Zhang, Z.; Cheng, Y.; Zhao, Z.; Gao, P.; Lou, X.; Xia, F.; Wang, S., 2016: A highly sensitive and facile graphene oxide-based nucleic acid probe: Label-free detection of telomerase activity in cancer patient's urine using AIEgens. NlmCategory="UNASSIGNED">Molecular beacon (MB)-based sensing platforms that consist of a fluorogen-quencher pair play an important role in medical and biological researches. However, the synthesis of both fluorogen and quencher in the...

Sumiyoshi, T., 1996: Effect of time of maturity on primary dormancy of seeds of Scirpus juncoides Roxb. subsp. juncoides. Effect of sowing date, drainage treatment of mother plant and time of maturity on primary dormancy of seeds of Scirpus juncoides subsp. juncoides was investigated at Tohoku National Agricultural Experiment Station. Under paddy field conditions, pr...

Anonymous, 1941: New 'Parca' boiler: Svenska Jarnvagsverkstaderna put out a producer-gas boiler for central heating.. Constructional details are given of the 'Parca Generatorpanna', a new type of central-heating boiler working on the producer-gas principle. The apparatus is produced by Svenska Jarnvagsverkstaderna, of Linkoping. A similar but larger mod...

Arnsten, J.H.; Rigotti, N.A.; Wood Reid, K.M.; Mckool, K.; Singer, D.E., 1996: Heavy cigarette smoking is an independent predictor of impaired functional status in hospitalized adults. Jgim 11(Suppl 1): 42

Rawat, M.; Prasad, D.J.shi, R.; Pant, G., 1999: Proanthocyanidins from Prunus armeniaca roots. Three isomeric A-type proanthocyanidins have been isolated from the root of Prunus armeniaca. They were identified as ent-epiafzelechin-(4alpha leads to 8; 2alpha leads to O leads to 7)-epiafzelechin (mahuannin A), ent-epiafzelechin-(4alpha leads...

Syvolap V.D.; Boev S.S., 1980: Electro cardiographic phenomenon in a patient with myo carditic cardio sclerosis. Vrachebnoe Delo (9): 57-58

Oleski, N.; Mahdavi, P.; Peiser, G.; Bennett, A.B., 1987: Transport Properties of the Tomato Fruit Tonoplast : I. Identification and Characterization of an Anion-Sensitive H-ATPase. An anion-sensitive H+-ATPase was identified in membrane vesicles isolated from mature green tomato fruit. The H+-ATPase was associated with a low density membrane population having a peak density of 1.11 g/cmsuperscript 3, and its activity was inh...

Cadot R., 1974: State of research on forage production in central ivory coast. Salette, J E And M Chenost (Ed ) Colloque Sur L'intensification De La Production Fourragere En Milieu Tropical Humide Et Son Utilisation Par Les Ruminants Conference on The Intensive Management Of Forage Production in The Humid Tropics, Utilisation By The Ruminants, May 24-29, 1971 Viii+266p Illus Institute National De La Researche Agronomique: Versailles, France 21-24