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Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats


, : Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats. American Journal of Physiology. Renal Physiology 302(12): F1606-F1615

Angiotensin (ANG)-(1–7) is known to attenuate diabetic nephropathy; however, its role in the modulation of renal inflammation and oxidative stress in type 2 diabetes is poorly understood. Thus in the present study we evaluated the renal effects of a chronic ANG-(1–7) treatment in Zucker diabetic fatty rats (ZDF), an animal model of type 2 diabetes and nephropathy. Sixteen-week-old male ZDF and their respective controls [lean Zucker rats (LZR)] were used for this study. The protocol involved three groups: 1) LZR + saline, 2) ZDF + saline, and 3) ZDF + ANG-(1–7). For 2 wk, animals were implanted with subcutaneous osmotic pumps that delivered either saline or ANG-(1–7) (1 ng·kg–1·min–1) (n = 4). Renal fibrosis and tissue parameters of oxidative stress were determined. Also, renal levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), ED-1, hypoxia-inducible factor-1α (HIF-1α), and neutrophil gelatinase-associated lipocalin (NGAL) were determined by immunohistochemistry and immunoblotting. ANG-(1–7) induced a reduction in triglyceridemia, proteinuria, and systolic blood pressure (SBP) together with a restoration of creatinine clearance in ZDF. Additionally, ANG-(1–7) reduced renal fibrosis, decreased thiobarbituric acid-reactive substances, and restored the activity of both renal superoxide dismutase and catalase in ZDF. This attenuation of renal oxidative stress proceeded with decreased renal immunostaining of IL-6, TNF-α, ED-1, HIF-1α, and NGAL to values similar to those displayed by LZR. Angiotensin-converting enzyme type 2 (ACE2) and ANG II levels remained unchanged after treatment with ANG-(1–7). Chronic ANG-(1–7) treatment exerts a renoprotective effect in ZDF associated with a reduction of SBP, oxidative stress, and inflammatory markers. Thus ANG-(1–7) emerges as a novel target for treatment of diabetic nephropathy.

US$19.90

PMID: 22492942

DOI: 10.1152/ajprenal.00063.2012


Other references

di Paolo, M.; Evangelisti, L.; Ambrosino, N., 2014: Unexpected death of a ventilator-dependent amyotrophic lateral sclerosis patient. Amyotrophic lateral sclerosis (ALS) is a fatal, progressive, neurodegenerative disease and most patients affected die of respiratory compromise and/or pneumonia within 2 3 years of diagnosis. As ALS progresses, ventilator assistance is required. I...

Mathiesen, A., 2002: Top grade solutions for Norwegian hospital. Health Estate 56(10): 49-51

Hampton, T., 2009: Afghan military medical school reopens, enrolls women in first class of cadets. JAMA 302(19): 2081-2082

Van Dijk, L.M.rtinus Servatius; Bun, G.J.hanna Maria; Heesakkers, C.F.anciscus Maria; Matysiak, N.L.dia, 2003: Method for preparing edible, crunchy material and product comprising such material. A method for preparing an edible, crunchy material comprising a batter containing a small amount of protein, 8-45% moisture, 35-60% sugar and 12-63% of a nut material and wherein the batter is heated at a temperature of 100-180degree C. for period...

Forgiarini Júnior, L.Alberto.; Rezende, J.Castilhos.; Forgiarini, S.Genebra.Ibrahim., 2015: Alveolar recruitment maneuver and perioperative ventilatory support in obese patients undergoing abdominal surgery. The development of abdominal surgery represents an alternative therapy for the morbidly obese; however, patients undergoing this surgical procedure often experience postoperative pulmonary complications. The use of alveolar recruitment maneuvers a...

Johnston, S.S.; Sheehan, J.J.; Shah, M.; Cappell, K.; Princic, N.; Smith, D.; Kalsekar, I., 2016: Cardiovascular event costs in patients with Type 2 diabetes mellitus. To quantify the cost of acute major adverse cardiac events (MACE; myocardial infarction [MI] and stroke) stratified by cardiovascular disease (CVD) risk factors in commercially, Medicare Supplemental-, and Medicaid-insured patients with type 2 dia...

Bjartveit, E., 1962: Prosthesis service after amputation of the extremities. Tidsskrift for den Norske Laegeforening 82: 691-693

Benois, A. du Merle, P.; Lafont, JP.; Marro, JP., 1978: L'activite oophage de la myrmecofaune dans differents milieux du Mont Ventoux (Vaucluse). The oophagous activity of ants was studied in 1972 and 1973 at 8 stations of Mt. Ventoux Vaucluse, France . Traps consisting of glass caps placed on the soil and filled with eggs of the Mediterranean flour moth, Anagasta kuehniella, were used. At...

Johnson L.C.; D.B.lt W.L.; Long M.T.; Ross J.J.; Sassin J.F.; Arthur R.J.; Walter R.D., 1972: Diagnostic factors in adult males following initial seizures a 3 year follow up. Archives of Neurology 27(3): 193-197

Wright, M.L.; Frim, E.K.; Bonak, V.A.; Baril, C., 1986: Metamorphic rate in Rana pipiens larvae treated with thyroxine or prolactin at different times in the light/dark cycle. Premetamorphic Rana pipiens tadpoles at Stages V to VIII on a 12L/12D cycle with photoperiod from 0800 to 2000 hr were treated with 30 micrograms/liter thyroxine (T4) by immersion for various daily 8-hr spans, or by daily intraperitoneal injection...