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Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise

, : Four weeks of normobaric "live high-train low" do not alter muscular or systemic capacity for maintaining pH and K⁺ homeostasis during intense exercise. Journal of Applied Physiology 112(12): 2027-2036

It was investigated if athletes subjected to 4 wk of living in normobaric hypoxia (3, m; 16 h/day) while training at 8–1,3 m ["live high-train low" (LHTL)] increase muscular and systemic capacity for maintaining pH and K+ homeostasis as well as intense exercise performance. The design was double-blind and placebo controlled. Mean power during 3-s all-out cycling was similar before and immediately after LHTL (65 ± 31 vs. 628 ± 32 W; n = 1) and placebo exposure (658 ± 22 vs. 66 ± 23 W; n = 6). Supporting the performance data, arterial plasma pH, lactate, and K+ during submaximal and maximal exercise were also unaffected by the intervention in both groups. In addition, muscle buffer capacity (in mmol H+·kg dry wt–1·pH–1) was similar before and after in both the LHTL (14 ± 12 vs. 14 ± 16) and placebo group (145 ± 2 vs. 14 ± 3). The expression of sarcolemmal H+ transporters (Na+/H+ exchanger 1, monocarboxylate transporters 1 and 4), as well as expression of Na+-K+ pump subunits-α1, -α2, and -β1 was also similar before and after the intervention. In conclusion, muscular and systemic capacity for maintaining pH and K+ balance during exercise is similar before and after 4 wk of placebo-controlled normobaric LHTL. In accordance, 3-s all-out sprint ability was similar before and after LHTL.


PMID: 22461443

DOI: 10.1152/japplphysiol.01353.2011

Other references

Kimura, G.; Mori, R., 1964: Comparative Studies Of Intra-Yolk Sac Proliferations Of Avian Type Tubercle Bacilli And Nonphotochromogens. Kekkaku 39: 458-463

Gromova N.S., 1980: The pollen complex of a Nazimovian suite in southern Primorye. Trudy - Vsesoyuznyy Ordena Lenina Nauchno-Issledovatel'skiy Geologicheskiy Institut im AP

Leung, S.O.; Shih, L.B.; Dion, A.S.; Goldenberg, D.M.; Hansen, H.J., 1994: Engineering a VK FR-1 carbohydrate addition site for drug conjugation using a B-cell lymphoma-specific MAb, LL2, as a prototype. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 511

Sugahara, S.; Ikezaki, H.; Abe, K.; Ogawa, R., 1993: Anesthetic management of a patient with juvenile hyaline fibromatosis: a case report. Juvenile hyaline fibromatosis (JHF) is a rare disease of autosomal recessive heredity characterized by multiple subcutaneous nodules, hypertrophy of the gingiva, and flexural contracture of the joints including those of the cervical vertebrae and...

Markova, A., 2002: Growth and dehydrogenase activity of Rhizobium leguminosarum biovar viceae at different zinc concentrations. This study aims to establish the influence of different Zn concentrations on growth and dehydrogenase [oxidoreductase] activity of Rhizobium leguminosarum bv. viceae strains, isolated from lentils (Lens culinaris). A total of 6 R. leguminosarum bv...

Atsushi Imaizumi, A.I.; Anitaa Liem, A.L.; Quand Ngo, Q.N.; Hung-Chi Chen, H.C., 2012: Free jejunal diversionary conduit flaps following radiation damage to the pharynx: a technique for regaining oral feeding while preserving vocal function. Radiotherapy is an accepted primary treatment modality for head and neck malignancies. However, in severe cases, the chronic radiation damage has resulted in dysphagia, aspiration and choking. Failure in conservative therapeutic strategies for thi...

Barnhurst, J.D.; Hennessy, D.J., 1952: The action of fish tissue on thiamin. 2. Identification of the pyrimidine moiety of icthiamin. Ultraviolet absorption spectra and results of a potentiometric titration of icthiamin dihydrobromide suggested that icthiamin contains a 2-methyl-4-aminopyrimidine-5-methylene moiety. R. Marshall.

Anonymous, 1991: Annual Review of Phytopathology. Reviews (23) are arranged under the section headings: prefatory chapter, pioneer leaders, appraisal of disease, pathogenic fungi, bacteria and other prokaryotes, nematodes and viruses, physiology, morphology and anatomy, molecular genetics, geneti...

Boonzaier, N.R.; Larkin, T.J.; Matys, T.; van der Hoorn, A.; Yan, J-Lin.; Price, S.J., 2017: Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma. Purpose To determine whether regions of low apparent diffusion coefficient (ADC) with high relative cerebral blood volume (rCBV) represented elevated choline (Cho)-to-N-acetylaspartate (NAA) ratio (hereafter, Cho/NAA ratio) and whether their volum...

Nonaka, Y., 2003: Model animals for muscular dystrophy. Experimental Animals 52(1): Suppl 14-7