+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of incremental exercise on airway and systemic inflammation in patients with COPD

, : Effect of incremental exercise on airway and systemic inflammation in patients with COPD. Journal of Applied Physiology 112(12): 2049-2056

Airway and systemic inflammation are features of chronic obstructive pulmonary disease (COPD), and there is growing interest in clarifying the inflammatory processes. Strenuous exercise induces an intensified systemic inflammatory response in patients with COPD, but no study has investigated the airway inflammatory and anti-inflammatory responses to exercise. Twenty steroid-naïve, ex-smokers with diagnosed COPD (forced expired volume in 1 s = 66 ± 12%) underwent baseline collection of venous blood and induced sputum followed by an incremental exercise test to symptom limitation 48 h later. Additional venous blood samples were collected following exercise at , 2, and 24 h, while induced sputum was collected 2 and 24 h after exercise. Sputum and blood samples were analyzed for differential cell count, CD4+ and CD8+ T lymphocytes (serum only), interleukin (IL)-6, IL-8, IL-1, chemokine (C-C motif) ligand 5 (CCL5), and high sensitivity C-reactive protein (serum only). There was an increase in the number of sputum eosinophils (cells/gram, P = .12) and a reduction in sputum IL-6 (P = .1) 24 h postexercise. Sputum IL-8 and CCL5 were also persistently decreased after exercise (P = .98 and P = .12, respectively), but sputum IL-1 did not change. There was a decrease in serum eosinophils 2 h after exercise (P = .14) and a reduction in serum CCL5 immediately following and 2 h postexercise (P < .1). Both serum eosinophils and CCL5 returned to baseline levels within 24 h. An acute bout of exercise resulted in a significant increase in the number of sputum eosinophils, which may be mediated by serum CCL5. However, there was also a reduction in sputum proinflammatory cytokines, suggesting some anti-inflammatory effect of exercise in the lungs of steroid-naïve patients with COPD.


PMID: 22500008

DOI: 10.1152/japplphysiol.01615.2011

Other references

Castaños, P.; Murelaga, X.; Arrizabalaga, A.; Iriarte, Mía-José., 2011: First evidence of Macaca sylvanus (Primates, Cercopithecidae) from the Late Pleistocene of Lezetxiki II cave (Basque Country, Spain). Journal of Human Evolution 60(6): 816-820

Nuccitelli, Richard, 2000: Some easy and effective ways for active scientists to improve science education. Molecular Biology of the Cell 11(Supplement): 425a, Dec

Williams, L.J.; Dunlop, J.P.; Abdi, Hé., 2012: Effect of age on variability in the production of text-based global inferences. As we age, our differences in cognitive skills become more visible, an effect especially true for memory and problem solving skills (i.e., fluid intelligence). However, by contrast with fluid intelligence, few studies have examined variability in...

Samuelsson, B., 1981: Oxidative products of arachidonate: leukotrienes, a new group of compounds, including slow-reacting substance of anaphylaxis (SRA-A). Kroc Foundation Series 14: 1-11

Rogers, J.J.W.; Feiss, P.G., 1998: People and the Earth: basic issues in the sustainability of resources and environment. The ways in which the planet limits or enhances human lives are examined. The geological restrictions on the ability to exploit resources (food, water, energy, minerals) from the earth, the effect human activity has on the earth, and the damage ca...

Bui, L.L.; Smith, A.J.; Bercovici, M.; Szalai, J.P.; Hanna, S.S., 2008: Minimising blood loss and transfusion requirements in hepatic resection. Substantial blood loss and the requirement for blood transfusion remain major considerations for hepatic surgeons. We analysed the impact of a systematic protocol aimed at reducing intraoperative blood loss and homologous blood (HB) transfusion as...

Voron, F.; Sokolenko, N., 1971: Further study of the F-group system in porcine blood. Soviet genetics: (Transl y 1973), 7 (1) 39-41

Portman, JE., 1991: Marine pollution 1990. Marine Pollution Bulletin, 223: 152-153

Heading, G.S.; Fuller, J.D.; Lyle, D.M.; Madden, D.Lynne., 2007: Using problem-based learning in public health service based training. This study explored the suitability and benefits of problem-based learning (PBL) in competency-based postgraduate public health training. The PBL was delivered within a rural retreat and included site visits. Qualitative semistructured interviews...

Jepsen, Jørgen.Riis.; Rasmussen, H.B., 2016: The metabolic syndrome among Danish seafarers: a follow-up study. The metabolic syndrome (MS) represents a cluster of risk factors related to insulin resistance. Metabolic syndrome is a strong risk factor for chronic metabolic and cardiovascular diseases and is related to nutritional factors, sleep patterns, wor...