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Inferring the role of inhibition in auditory processing of complex natural stimuli


, : Inferring the role of inhibition in auditory processing of complex natural stimuli. Journal of Neurophysiology 107(12): 3296-3307

Intracellular studies have revealed the importance of cotuned excitatory and inhibitory inputs to neurons in auditory cortex, but typical spectrotemporal receptive field models of neuronal processing cannot account for this overlapping tuning. Here, we apply a new nonlinear modeling framework to extracellular data recorded from primary auditory cortex (A1) that enables us to explore how the interplay of excitation and inhibition contributes to the processing of complex natural sounds. The resulting description produces more accurate predictions of observed spike trains than the linear spectrotemporal model, and the properties of excitation and inhibition inferred by the model are furthermore consistent with previous intracellular observations. It can also describe several nonlinear properties of A1 that are not captured by linear models, including intensity tuning and selectivity to sound onsets and offsets. These results thus offer a broader picture of the computational role of excitation and inhibition in A1 and support the hypothesis that their interactions play an important role in the processing of natural auditory stimuli.

US$19.90

PMID: 22457454

DOI: 10.1152/jn.01173.2011


Other references

Hundeby, David Robert, 2000: Agricultural implement with down-force control. Down-force control is provided by a top-link, which presses down the rear end of a tool-bar carrying multiple rows of seeder tools. The height of the tool bar is set front and rear during operation. The top-link includes a hydraulic ram. The ram i...

Gomi J., 1970: Treatment of severe cavitary pulmonary tuberculosis resistant to major drugs. Umezawa, Hameo (President) Progress in Antimicrobial And Anticancer Chemotherapy, Vols 1 And 2 Proceedings Of The 6th International Congress Of Chemotherapy Xxvii + 1096p (Vol 1) Illus Xvi + 1252p + Xxiii (Vol 2) Illus University Park Press: Baltimore, Md , U S A ; Manchester, England 627-631

Porotikova, I.E.; Adamyan, L.V.; Gavrilova, T.Y.; Kulabukhova, E.A., 2016: Intraoperative Monitoring and Evaluation of MRI in Women of Reproductive Age After Previously Performed Uterine Artery Embolization (UAE) and MRgFUS Ablation of Fibroids. Journal of Minimally Invasive Gynecology 22(6s): S235-S235

Leon, H.M.; Tabor, M.H., 2014: Endoscopic appearance of a healed skull base resection reconstructed with a pedicled nasoseptal flap. Ear, Nose, & Throat Journal 92(10-11): E34-E34

Hicks, J.T., 1968: Hospital-acquired infections. 3. The role, authority and membership of the infection committee. Hospital Management 105(3): 55-7 Contd

Burchard Ulrich; Pagano Renato, 1996: The blowpipe analysis of minerals; Part 2, Apparatus and accessories. Rivista Mineralogica Italiana 1996(2): 121-147

Anthony, M.P.B.rrows, J.N.D.parc, S.; JMoehrle, J.; Wells, T.N., 2012: The global pipeline of new medicines for the control and elimination of malaria. Over the past decade, there has been a transformation in the portfolio of medicines to combat malaria. New fixed-dose artemisinin combination therapy is available, with four different types having received approval from Stringent Regulatory Author...

Michelli, H., 1951: Cyclic manifestations indicating the presence of free nerve endings and of synapses in the molecular layer of the cerebellum of the rat. Experientia 7(11): 426-427

Leont yev Y.I., 1967: K voprosu otsenki neftegazonosnosti mezozoyskikh kollektorov mestorozhdeniy zapadno-sibirskoy nizmennosti po dannym promyslovoy geofiziki (on the problem of calculating the oil and gas possibilities of mesozoic reservoirs of the fields of the west s. Razvedochnaya Geofizika 19: 51-54

Claydon, T.W.; Rose, T.; Nichols, C.G.; Boyett, M.R., 2003: Mutation of Kir31-F181 in the Kir31/Kir34 K+ channel affects channel kinetics and agonist activation. Biophysical Journal 84(2 Part 2): 80a, February