+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

HPV Modulation of Mitochondrial ncRNAs

, : HPV Modulation of Mitochondrial ncRNAs.

The study of RNA and DNA oncogenic viruses has proved invaluable in the discovery of key cellular pathways that are rendered dysfunctional during cancer progression. An example is high risk human papillomavirus (HPV), the etiological agent of cervical cancer. The role of HPV oncogenes in cellular immortalization and transformation has been extensively investigated. We reported the differential expression of a family of human mitochondrial non-coding RNAs (ncRNAs) between normal and cancer cells. Normal cells express a sense mitochondrial ncRNA (SncmtRNA) that seems to be required for cell proliferation and two antisense transcripts (ASncmtRNAs). In contrast, the ASncmtRNAs are down-regulated in cancer cells. To shed some light on the mechanisms that trigger down-regulation of the ASncmtRNAs, we studied human keratinocytes (HFK) immortalized with HPV. Here we show that immortalization of HFK with HPV-16 or 18 causes down-regulation of the ASncmtRNAs and induces the expression of a new sense transcript named SncmtRNA-2. Transduction of HFK with both E6 and E7 is sufficient to induce expression of SncmtRNA-2. Moreover, E2 oncogene is involved in down-regulation of the ASncmtRNAs. Knockdown of E2 in immortalized cells reestablishes in a reversible manner the expression of the ASncmtRNAs, suggesting that endogenous cellular factors(s) could play functions analogous to E2 during non-HPV-induced oncogenesis.


Other references

Lagier, G., 1980: Bismuth encephalopathies outside France. Therapie 35(3): 315-317

Zhang, G.M.; Gu, Y.D.; Chen, D.S.; Yan, J.G.; Cheng, X.M., 1990: Root avulsion of brachial plexus in infants and children. Twenty-one patients, under 6 years of age, with root avulsion of the brachial plexus were treated from 1975 to 1987. Among them, 9 had root avulsion of the upper trunk, 2 root avulsion of the lower trunk with middle trunk broken, and 10 root avuls...

Hande Kazak; Bahar Gürleyendag; Annarita Poli; Ebru Toksoy Öner; Barbara Nicolaus, 2007: Exopolysaccharide production by Halomonas strains isolated from Turkey. Journal of Biotechnology 131(2-supp-S)

Braveny P.; Simurda J.; Simurdova M., 1992: Voltage dependence of force restitution in papillary muscles. Journal of Molecular & Cellular Cardiology 24(SUPPL 1): S269

Lee Gwang H.; Bryant William R.; Watkins Joel S., 1989: Salt structures and sedimentary basins in the Keathley Canyon area, northwestern Gulf of Mexico; their development and tectonic implications. Annual Research Conference Gulf Coast Section

D'-Arrigo, V., 1978: Lead content in papers in contact with food products. Industrie alimentari 17(6): 491-495

Niederdellmann, H.; Schilli, W., 1980: Traction screw osteosynthesis in the treatment of fracture of the angle of mandible. The application of traction strapping with a single cortical screw in the form of lag screw osteosynthesis has been suggested for the treatment of angular factures of the mandible. This is also possible in those cases where there are other mandibu...

Iannetti, M.; Pastorini, C.; Masperone, M.A.; Vinci, P.; Perugini, P.; Bertolotti, M.C.; Griffo, R.; Chiarella, F.; Caponnetto, S., 1977: Function of the right ventricle and pulmonary hemodynamics during isometric exercise in patients with compensated chronic pulmonary heart disease. Bollettino Della Societa Italiana di Cardiologia 22(9): 1515-1517

Pesce, G.; Volpe, G.; Volpe, G.; Sasso, A., 2014: Long-term influence of fluid inertia on the diffusion of a Brownian particle. We experimentally measure the effects of fluid inertia on the diffusion of a Brownian particle at very long time scales. In previous experiments, the use of standard optical tweezers introduced a cutoff in the free diffusion of the particle, which...

Compton, C., 2017: Precision Medicine Core: Progress in Prognostication-Populations to Patients. Annals of Surgical Oncology