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How Breast Cancer Cells Invade Bonediams;


, : How Breast Cancer Cells Invade Bonediams;.

Hen cancerous cells break loose from the original tumor and spread to other organs, the lethality of the disease rises. In this Paper of the Week, Roger R. Gomis at the Institute for Research in Biomedicine in Spain and colleagues looked into how metastatic breast cancer cells invade bone. They focused on a gene called NOG, which is heavily involved in bone-remodeling processes and is a key player in bone metastasis. The protein NOG antagonizes the function of bone morphogenetic proteins, a class of growth factors. Gomis and colleagues demonstrated that NOG is expressed later in the metastatic process, once the breast cancer cells have left the primary tumor site. The protein helps the cells colonize and survive in bone by promoting osteoclast differentiation, bone degradation, and metastatic lesions.jbc;287/25/21356/FU1F1FU1Images of mice injected with SKBr3 control and SKBr3 NOG cells at days , 1, and 65 after injection.

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