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RNASTAR: an RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs


, : RNASTAR: an RNA STructural Alignment Repository that provides insight into the evolution of natural and artificial RNAs. Rna 18(7): 1319-1327

Automated RNA alignment algorithms often fail to recapture the essential conserved sites that are critical for function. To assist in the refinement of these algorithms, we manually curated a set of 148 alignments with a total of 96 unique sequences, in which each alignment was backed by at least one crystal or NMR structure. These alignments included both naturally and artificially selected molecules. We used principles of isostericity to improve the alignments from an average of 83%–94% isosteric base pairs. We expect that this alignment collection will assist in a wide range of benchmarking efforts and provide new insight into evolutionary principles governing change in RNA structural motifs. The improved alignments have been contributed to the Rfam database.

US$19.90

PMID: 22645380

DOI: 10.1261/rna.032052.111


Other references

Pedersen, S.; Rugh, S., 1988: Properties and application of Sweetzyme T - a new immobilized glucose isomerase produced by a strain of Streptomyces murinus. Sweetzyme T is an immobilized glucose isomerase for use in the manufacture of HFS. It is produced from a strain of Streptomyces murinus, unlike other types of Sweetzyme, which are produced from Bacillus coagulans. The physical properties of Sweetz...

Dugas, E.; Low, N.C.P.; Rodriguez, D.; Burrows, S.; Contreras, Gèle.; Chaiton, M.; O'Loughlin, J., 2013: Early predictors of suicidal ideation in young adults. To identify early predictors of suicidal ideation in young adults, and to determine when specific time-varying determinants become important in predicting later suicidal ideation. Data were available for 877 participants in the Nicotine Dependence...

Kruckeberg, A.R., 1992: Serpentine biota of western North America Legacy of the past, present status and future needs. Baker, A J M , Proctor, J , Reeves, R D The vegetation of ultramafic (Serpentine) soils : 19-33

Okumura, S.; Harada, H.; Saiki, H., 1974: The variation in the cell wall thickness along the length of a conifer tracheid. Describes, and illustrates with scanning electron micrographs of transverse sections of late wood, a study of the variations in thickness of the S2 layer along the length of a mature Pinus densiflora tracheid. In late-wood tracheids the thickness...

Gillespie, J.B.; Lindberg, J.D.; Laude, L.S., 1975: Kubelka-munk optical coefficients for a barium sulfate white reflectance standard. Applied Optics 14(4): 807-809

Kaufmann, D., 2012: Science as cultural practice: psychiatry in the First World War and Weimar Germany. Journal of Contemporary History 34(1): 125-145

Hald, S.; Schioldan, A.Grethe.; Moore, M.E.; Dige, A.; Lærke, H.Nygaard.; Agnholt, Jørgen.; Bach Knudsen, K.Erik.; Hermansen, K.; Marco, M.L.; Gregersen, Søren.; Dahlerup, J.F., 2016: Effects of Arabinoxylan and Resistant Starch on Intestinal Microbiota and Short-Chain Fatty Acids in Subjects with Metabolic Syndrome: A Randomised Crossover Study. ClinicalTrials.gov NCT01618526.

Bloom, K.Kaye.; Ellen, J.; Kaye, D., 2004: Occipital neuralgia and twelfth nerve palsy from a chondromyxoid fibroma. The purpose of this case report is to record the unusual combination of occipital neuralgia and hypoglossal nerve palsy causing dysarthria, dysphagia, and unilateral weakness of tongue protrusion, with no other neurological findings. The cause was...

Voso, M.T.resa; D'alo', F.; Scardocci, A.; Guidi, F.; Pagano, L.; Hohaus, S.; Leone, G., 2002: Polymorphisms of CYP1A1 and Glutathione S-Transferase and Susceptibility to Adult Acute Myeloid Leukemia. The origin of acute myeloid leukemia (AML) may be explained by the combination of genetic susceptibility factors and environmental exposure. Chemical carcinogens react with DNA after metabolic activation, followed by detoxification. Members of cyt...

Zhao, X.; Liu, M.; Wu, N.; Ding, L.; Liu, H.; Lin, X., 2010: Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro. p53 protein is an important regulation factor that can bind to p53 mRNA to regulate its translation in human and murine. To determine if a similar interaction exists in zebrafish and if the interaction affects zebrafish development, we cloned and...