+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Multigene families in Trypanosoma cruzi and their role in infectivity

, : Multigene families in Trypanosoma cruzi and their role in infectivity. Infection and Immunity 80(7): 2258-2264

The Trypanosoma cruzi genome contains the most widely expanded content (∼12,000 genes) of the trypanosomatids sequenced to date. This expansion is reflected in the high number of repetitive sequences and particularly in the large quantity of genes that make up its multigene families. Recently it was discovered that the contents of these families vary between phylogenetically unrelated strains. We review the basic characteristics of trans-sialidases and mucins as part of the mechanisms of immune evasion of T. cruzi and as ligands and factors involved in the cross talk between the host cell and the parasite. We also show recently published data describing two new multigene families, DGF-1 and MASP, that form an important part of the scenario representing the complex biology of T. cruzi.


PMID: 22431647

DOI: 10.1128/IAI.06225-11

Other references

Dowling, G.B., 1924: Persistent Erythema Multiforme. Proceedings of the Royal Society of Medicine 17(Dermatol Sect): 90-90

Nakashima, H.; Fujii, H.; Oida, A.; Momozu, M.; Kawase, Y.; Kanamori, H.; Aoki, S.; Yokoyama, T., 2007: Parametric analysis of lugged wheel performance for a lunar microrover by means of DEM. The purpose of this study was to develop a numerical tool to simulate the performance of lugged wheels designed for a lunar microrover. The performance was analyzed using a Discrete Element Method (DEM) whose accuracy was validated for interaction...

Andrade,, 2010: 6th World Congress of fluency disorders. Pro-Fono 21(3): 183-188

Carter, W.W., 1980: Incidence and control of Myrothecium roridum on cantaloup in relation to time of fungicide application. A mixture of benomyl and zinc ion-maneb [mancozeb] complex controlled Myrothecium roridum on cantaloup leaves and stems. No relationship was found between rainfall, time of fungicide application and incidence of M. roridum. Primary infection by th...

Rombouts, J.E.; Sijpesteijn, A.K.ars, 1958: The chemotherapeutic effect of pyridine-2-thiol-N-oxide and some of its derivatives on certain plant diseases. Pyridine-2-thiol-N-oxide and its carboxymethyl derivative have limited systemic properties which may result in a restricted protection of broad bean plants against Botrytis fabae and of cucumber plants against Cladosporium cucumerinum. Root,applic...

Zöller, H.; Gross, W.; Schreiner, W., 1979: Hemorrhagic diathesis in patients with malignant neoplasms. Clotting analysis in 30 patients with bleeding complications in malignant hematological diseases revealed the following troubles: The global tests, Quick's index and partial thromboplastin time markedly differed from normal. Activity of clott...

Bacigalupo, J., 1930: Oeufs de Oxyuris incognita ou Heterodera radicicola. Compte Rendu des Seances de la Societe de Biologie Paris, 105: 118-119

Gada V.P.; Nandal N.V.; Balsara J.J.; Chandorkar A.G., 1983: Effect of alpha methyl p tyrosine on neuroleptic induced catalepsy in the rat. Indian Journal of Physiology & Pharmacology 27(3): 241-244

Blasco Santamaría, R., 1986: Nursing in the university 10 years from now. Revista de Enfermeria 9(100): 60-64

Buggs, R.J.A.; Wendel, J.F.; Doyle, J.J.; Soltis, D.E.; Soltis, P.S.; Coate, J.E., 2015: The legacy of diploid progenitors in allopolyploid gene expression patterns. Allopolyploidization (hybridization and whole-genome duplication) is a common phenomenon in plant evolution with immediate saltational effects on genome structure and gene expression. New technologies have allowed rapid progress over the past deca...