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Impact of first-line antifungal agents on the outcomes and costs of candidemia


, : Impact of first-line antifungal agents on the outcomes and costs of candidemia. Antimicrobial Agents and ChemoTherapy 56(7): 3950-3956

Candida species are the leading causes of invasive fungal infection among hospitalized patients and are responsible for major economic burdens. The goals of this study were to estimate the costs directly associated with the treatment of candidemia and factors associated with increased costs, as well as the impact of first-line antifungal agents on the outcomes and costs. A retrospective study was conducted in a sample of 199 patients from four university-affiliated tertiary care hospitals in Korea over 1 year. Only costs attributable to the treatment of candidemia were estimated by reviewing resource utilization during treatment. Risk factors for increased costs, treatment outcome, and hospital length of stay (LOS) were analyzed. Approximately 65% of the patients were treated with fluconazole, and 28% were treated with conventional amphotericin B. The overall treatment success rate was 52.8%, and the 30-day mortality rate was 47.9%. Hematologic malignancy, need for mechanical ventilation, and treatment failure of first-line antifungal agents were independent risk factors for mortality. The mean total cost for the treatment of candidemia was $4,743 per patient. Intensive care unit stay at candidemia onset and antifungal switch to second-line agents were independent risk factors for increased costs. The LOS was also significantly longer in patients who switched antifungal agents to second-line drugs. Antifungal switch to second-line agents for any reasons was the only modifiable risk factor of increased costs and LOS. Choosing an appropriate first-line antifungal agent is crucial for better outcomes and reduced hospital costs of candidemia.

US$19.90

PMID: 22526315

DOI: 10.1128/AAC.06258-11


Other references

David V.Fitterman, 1976: Theoretical resistivity variations along stressed strike-slip faults. Journal of Geophysical Research 81(26): 4909-4915

Youn, H-J.; Chung, W-S.; Hong, S-J., 2002: Tumour feeding vessel in metastatic intracardiac mass demonstrated by transthoracic Doppler echocardiography. Heart 88(3): 216-216

Usov, A.; Adamyants, K.; Yarotsky, S.; Anoshina, A.; Kochetkov, N., 1973: The isolation of a sulphated mannan and a neutral xylan from the red seaweed Nemalion vermiculare Sur. Carbohydrate Research 26(1): 282-283

Becker, K.; Krebs, B.; Schirmer, R.H., 1991: Protein-chemical standardization of the erythrocyte glutathione reductase activation test (EGRAC test). Application to hypothyroidism. The erythrocyte glutathione reductase activation coefficient (EGRAC) is an index of riboflavin deficiency or, more exactly, of FAD deficiency in man. In this report a sensitive version of the EGRAC test is introduced that is based on the molecular...

Vainshtein, V.A.; Chebotareva, S.M.; Verba, G.G.; Skvirskaya, T.Y., 1981: Use of chromatographic methods in the analysis of levorin and its medicinal forms 1. optimization of conditions for the quantitative determination of levorin and some of its derivatives. The possibility of using quantitative analysis by TLC and paper chromatography with eluation and spectrophotometric eluates for levorin, isolevorin and levoridon was investigated. Active components in tested solvent systems are almost completely s...

Silber, Mark, 1985: Dissolving defensiveness. Defensiveness is a common reaction to a perceived threat, or an attempt by an individual to protect his/her personal and public image. Supervisors must occasionally "defuse" a defensive colleague or staffer in order to solve a particular...

Pannuti, C.S., 1991: The costs of hospital infection control in a developing country. Infection Control and Hospital Epidemiology 12(11): 647-648

Balakshin G.D.; Savrasov D.I.; Fedorov N.N., 1967: On the possibility of using aeromagnetic surveying in prospecting for kimberlite- or carbonatite-bearing bodies in yakutia. Razvedka i Okhrana Nedr 3: 43-46

Anonymous, 1949: Central Arecanut Committee constituted. A Central Arecanut Committee for the improvement and development of the production and marketing of the areca nut and its products is to be established by the Government of India. Its aims include the production, testing and distribution of improv...

Posudin, Y.I.; Trofimenko, A.L.; Koval' , Y.M.; Palekha, N., 1993: Spectral characteristics of hairs as genotypic indices of variation in animals. Hair samples from 6 body regions from a "Scottish" pony stallion, an Estonian Pony mare and their foal were examined by fluorescent microscopy for quantitative evaluation of the intensity of fluorescence of pigment. Values for intensity...