geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

In vitro susceptibility of Pythium insidiosum isolates to aminoglycoside antibiotics and tigecycline


, : In vitro susceptibility of Pythium insidiosum isolates to aminoglycoside antibiotics and tigecycline. Antimicrobial Agents and ChemoTherapy 56(7): 4021-4023

This study evaluated the in vitro activity of aminoglycoside antibiotics and tigecycline against Pythium insidiosum. The susceptibility tests were carried out using the broth microdilution method in accordance with the CLSI document M38-A2. MIC values for gentamicin, neomycin, paromomycin, and streptomycin ranged from 32 to 64 mg/liter, and the minimal fungicidal concentration (MFC) ranged from 32 to 128 mg/liter, which are incompatible with safe concentrations of these drugs in plasma in vivo. Tigecycline showed the lowest MIC (0.25 to 2 mg/liter) and MFC (1 to 8 mg/liter) range values. The in vitro susceptibility observed to tigecycline makes this drug a good option in future tests in vitro and in vivo for the management of pythiosis.

US$19.90

PMID: 22508303

DOI: 10.1128/AAC.00073-12


Other references

Komoda, T.; Sakagishi, Y., 1978: The function of carbohydrate moiety and alteration of carbohydrate composition in human alkaline phosphatase ec 3.1.3.1 iso enzymes. The effects of glycosidase digestion on the alkaline phosphatase [EC 3.1.3.1] isoenzymes were investigated. Changes in physicochemical properties, activity, affinity for various lectins and blood group antisera, carbohydrate composition and biolog...

Mazzoni, G.; Salleh, S.M.; Freude, K.; Pedersen, H.S.; Stroebech, L.; Callesen, H.; Hyttel, P.; Kadarmideen, H.N., 2017: Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics. The Ovum Pick Up-In vitro Production (OPU-IVP) of embryos is an advanced reproductive technology used in cattle production but the complex biological mechanisms behind IVP outcomes are not fully understood. In this study we sequenced RNA of granul...

Rich, C., 1971: New knowledge of calcium homeostasis--advance of a once backward field. California Medicine 114(3): 75-76

Yotsui, T., 1976: Seasonal occurrence and sporangia formation of nemacystus decipiens chordariales phaeophyta. N. decipiens (Suringar) Kuckuck, a favorite edible alga in Japan, was studied ecologically at Omura and Nomozaki, Nagasaki, Prefecture. The growing period of the thalli at the 2 localities was very different. At Omura, young thalli appeared in ear...

Niemz, P.; Sonderegger, W., 2003: Analysis of the correlation between selected wood properties among each other and the density of 103 wood species. Several correlations of the properties of 103 wood species published in the technical literature were calculated and the influence of their structure was determined. In all investigated wood species a good correlation exists between the density an...

Benson, R.B., 1966: A new genus of the Lycaotini (Blennocampinae) in Turkey (Hymenoptera: Tenthredinidae). Proct. Soc. Lond. (B): 75-77

Axelrod, D.I., 1948: Climate and evolution in western North America during Middle Pliocene time. Late Tertiary floras suggest mild and warm dry-climate characterized the western U. S. during Middle Pliocene time. Warm climate also seems indicated for the Middle Pliocene of Europe, and may form a basis for wide correlation if sub- stantiated....

Encinas, O.; Mora, N., 2005: Causes of wood biodegradation in ground contact in the east of Venezuela. Following the methodology of the International Union of Organizations of Forest Investigation for the study on wood durability, a National Net of Cemeteries of Stakes was established to evaluate the natural and induced durability of Venezuelan spe...

Singh, S.K.; Fremes, S.E., 2006: The role of vessel wall physiology in predicting coronary bypass graft patency. Journal of Cardiothoracic Surgery 1: 5-5

Geijskes, D.C., 1953: Nuptial flighttime of Atta-ants in Surinam. Investigations on the development of sexual forms and the seasonal occurrence of nuptial flights of the leaf-cutting ants, Atta cephalotes (L.) and A. sexdens (L.), were made in Dutch Guiana with a view to finding the best time for carrying out ch...