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Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3


, : Cell adhesion molecule 1 (CADM1) on mast cells promotes interaction with dorsal root ganglion neurites by heterophilic binding to nectin-3. Journal of Neuroimmunology 250(1-2): 50-58

Cell adhesion molecule 1 (CADM1) on mast cells promotes attachment and communication with neurons by homophilic binding. However, we found that mast cell CADM1 was responsible for both the attachment of mast cells to dorsal root ganglia (DRG) neurites and their calcium responses to activated DRG neurites, despite the low expression of CADM1 in DRG. Instead, nectin-3 was expressed on DRG neurons and localized to regions of cell cell contact. A neutralizing antibody to nectin-3 inhibited both mast cell attachment and subsequent calcium responses. This suggests that heterophilic binding between CADM1 and nectin-3 mediates functional DRG mast cell interactions in vitro.

US$19.90

PMID: 22703826

DOI: 10.1016/j.jneuroim.2012.05.016


Other references

Senthilnathan P.; Ganczarczyk J.J., 1988: Determination of biomass in activated sludge containing large quantities of carbonaceous solid carriers. The exact estimation of biomass in the presence of carbonaceous carriers is an unresolved problem. Inaccuracy arises from the use of mixed liquor volatile suspended solids (MLVSS) determination as the measure of biomass, due to the votalization pr...

Algueró, M.; Hungría, T.; Amorín, H.; Ricote, Jús.; Galy, J.; Castro, A., 2007: Relaxor behavior, polarization buildup, and switching in nanostructured 0.92 PbZn1/3Nb2/3O3-0.08 PbTiO3 ceramics. The relaxor-type behavior, electrical polarization buildup, and switching in 0.92Pb(Zn(1/3)Nb(2/3))O(3)-0.08PbTiO(3) nanostructured ceramics with a grain size of approximately 20 nm is reported for the first time. This composition presents the hig...

Peycelon, R.; Replumaz, P., 1956: Rectosigmoidectomy for neoplasm of rectum and removal of adenoma of pancreatic head for hyperinsulinism with hypoglycemic accidents performed at a month's interval. Lyon Chirurgical 51(1): 94-96

Stepanov, I.; Feuer, R.; Jensen, J.; Hatsukami, D.; Hecht, S.S., 2006: Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails. Numerous studies have quantified total cotinine (the sum of cotinine and cotinine-N-glucuronide) and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol [NNAL; the sum of NNAL and its O- and N-glucuronides (NNAL-Glucs)] in the urine and blood of s...

Skibniewska, K.A.; Smoczyński, S.S., 1999: The influence of cooking on radiocaesium contamination of edible mushrooms. Radiocaesium concentration in some kinds of edible mushrooms collected in October 1990 has been determined to evaluate the radiocaesium activity 5 years after Chernobyl accident. The highest activity was found in Xerocomus subtomentosus (1080.5 Bq...

Biagi, F.; Musiani, F.; Ciurli, S., 2013: Structure of the UreD-UreF-UreG-UreE complex in Helicobacter pylori: a model study. The molecular details of the protein complex formed by UreD, UreF, UreG, and UreE, accessory proteins for urease activation in the carcinogenic bacterium Helicobacter pylori, have been elucidated using computational modeling. The calculated struct...

Thijssen H.H.W.; Baars L.G.M., 1988: The mechanism of the stereoselectivity of 4 hydroxycoumarin anticoagulants. Naunyn-Schmiedeberg's Archives of Pharmacology 337(SUPPL): R12

Beamish, A.J.; Reinehr, T., 2017: Should bariatric surgery be performed in adolescents?. Adolescent obesity has markedly increased worldwide in both its extent and prevalence in recent decades and obesity prevention strategies are failing. As a result, effective treatment strategies are urgently needed. As behavioral and pharmacologic...

Mansour, F.A.; Mostafa, M.A.; Sherif, A.A., 1982: Studies on pathogenic and rhizospheric Fusarium species associated with tomato plants in Mansoura District. I. Identification of Fusarium species and investigation of their deteriorative potentialities. Of the 4 F. isolates, F. oxysporum (2) and F. solani were from root tissues and F. semitectum [F. pallidoroseum] from the rhizosphere of wilted tomatoes. The morphological characteristics of the isolates are discussed. One F. oxysporum isolate was...

Gray, J.Roach., 2007: HPV vaccination: should it be mandatory for entry into public school?. Nursing for Women's Health 11(2): 133-138