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Evidence of multiple introductions of HIV-1 subtype C in Angola


, : Evidence of multiple introductions of HIV-1 subtype C in Angola. Infection, Genetics and Evolution 12(7): 1458-1465

HIV-1 subtype C is the most prevalent group M clade in southern Africa and some eastern African countries. Subtype C is also the most frequent subtype in Angola (southwestern Africa), with an estimated prevalence of 1 2%. In order to better understand the origin of the HIV-1 subtype C strains circulating in Angola, 31 subtype C pol sequences of Angolan origin were compared with 195 subtype C pol sequences sampled in other African countries. Phylogenetic analyses reveal that the Angolan subtype C sequences were distributed in 16 different lineages that were widely dispersed among other African strains. Ten subtype C Angolan lineages were composed by only one sequence, while the remaining six clades contain between two and seven sequences. Bayesian phylogeographic analysis indicates that most Angolan clades probably originated in different southern African countries with the exception of one lineage that most likely originated in Burundi. Evolutionary analysis suggests that those Angolan subtype C clades composed by ?2 sequences were introduced into the country between the late 197s and the mid 2s. The median estimated time frame for the origin of those Angolan lineages coincides with periods of positive migration influx in Angola that were preceded by phases of negative migratory outflow. These results demonstrate that the Angolan subtype C epidemic resulted from multiple introductions of subtype C viruses mainly imported from southern African countries over the last 3years, some of which have been locally disseminated establishing several autochthonous transmission networks. This study also suggests that population mobility between Angola and southern African countries during civil war (1974 22) may have played a key role in the emergence of the Angolan subtype C epidemic. We investigate the origin of HIV-1 subtype C viruses circulating in Angola. Multiple introductions of HIV-1 subtype C were detected in Angola. Most subtype C viruses introduced in Angola originated in southern Africa. Several autochthonous networks of subtype C transmission were identified. Origin of local transmission networks coincides with periods of migration influx.

US$19.90

PMID: 22634597

DOI: 10.1016/j.meegid.2012.05.005


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