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Transcriptional regulators that differentially control dendrite and axon development


, : Transcriptional regulators that differentially control dendrite and axon development. Frontiers in Biology 7(4): 292-296

Neurons are the basic units of connectivity in the nervous system. As a signature feature, neurons form polarized structures: dendrites and axons, which integrate either sensory stimuli or inputs from upstream neurons and send outputs to target cells, respectively. The separation of dendritic and axonal compartments is achieved in two steps during development: 1) dendrite and axon specification: how neurites are initially specified as dendrites and axons; and 2) dendrite and axon commitment: how dendrites and axons are committed to distinct compartmental fates and architectures. To understand neural circuit assembly and to correct erroneous dendrite or axon growth in a compartment-specific manner, it is essential to understand the regulatory mechanisms underlying dendrite and axon commitment. Compared to extensive studies on dendrite and axon specification, little is known about the molecular mechanisms exclusively dedicated to dendrite or axon commitment. Recent studies have uncovered the requirement of transcriptional regulation in this process. Here, we review the studies on transcriptional regulators: Dar1, p3-SnoN, NeuroD, which have been shown to separate dendrite- and axon-specific growth of the same neuron type after compartmental fates are specified.

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DOI: 10.1007/s11515-012-1234-y


Other references

Thanevala, S.M.; Chugh, S., 1961: Eclampsia associated with haemorrhagic diathesis. Indian Medical Journal 55: 193-196

Telford, S.R.J.; Tonn, R.J.; Gonzalez, J.J.; Court, P.B., 1981: Dynamics of trypanosome infections in the mammals of the dry tropical forests of the high plains of Venezuela. From an initial study of 750 mammals of 31 species, Didelphis marsupialis was found to be the principal reservoir host of Trypanosoma cruzi. Of 434 D. marsupialis captured in a later study, 52.8, 7.4, and 6.0% were positive by xenodiagnosis for T....

Grimsrud, O.K.; Dugstad, G., 1975: A simple method for embedding anatomical specimens. A simple embedding method for brain slices using epoxy resin is described. The embedding can be done immediately after cutting the brain and can be completed in 5-6 hrs. Discoloration of the slices is insignificant.

Berl, D., 1982: Note sur l'utilisation de pieges biconiques dans le capture de simulies. Cahiers O.R.S.T.O.M. (Office de la Recherche Scientifique et Technique Outre-Mer) Serie Entomologie Medicale et Parasitologie, 203: 171-173

Akiyama, T.; Kobayashi, K.; Ohtsuka, Y., 2011: Electroclinical characterization and classification of symptomatic epilepsies with very early onset by multiple correspondence analysis. To characterize very early onset symptomatic epilepsies electroclinically, to identify meaningful factors to delineate epilepsy syndromes under this category, and to test validity of the current syndromic organization of these epilepsies by the In...

Krystufek, B.; Tvrtkovic, N., 1984: Redescription of Arvicola terrestris illyrica (Barrett-Hamilton, 1899) - Rodentia, Mammalia. Acta Biologica Iugoslavica Serija G Biosystematicka, 102: 91-97

Saitoh, J-ichi.; Saito, Y.; Kazumoto, T.; Kudo, S.; Ichikawa, A.; Hayase, N.; Kazumoto, K.; Sakai, H.; Shibuya, K., 2010: Therapeutic effect of linac-based stereotactic radiotherapy with a micro-multileaf collimator for the treatment of patients with brain metastases from lung cancer. To assess the efficacy of hypofractionated linac-based stereotactic radiotherapy with a micro-multileaf collimator (mMLC) in lung cancer patients with brain metastases. Seventy-eight lesions of brain metastases in 49 lung cancer patients treated b...

Scutchfield, F.Douglas.; Howard, A.F., 2011: Moving on upstream: the role of health departments in addressing socioecologic determinants of disease. American Journal of Preventive Medicine 40(1 Suppl 1): S80-S83

Michalke, B., 1994: Quality control in speciation investigations. Information is provided about interferences in speciation investigations. Reasons for contamination and losses, stability problems, metal transfer effects or identification problems are ruled out and possible consequences are named. Logically, sol...

van den Heuvel, M.P.; Scholtens, L.H.; Turk, E.; Mantini, D.; Vanduffel, W.; Feldman Barrett, L., 2016: Multimodal analysis of cortical chemoarchitecture and macroscale fMRI resting-state functional connectivity. The cerebral cortex is well known to display a large variation in excitatory and inhibitory chemoarchitecture, but the effect of this variation on global scale functional neural communication and synchronization patterns remains less well understo...