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NFκB signaling regulates embryonic and adult neurogenesis


, : NFκB signaling regulates embryonic and adult neurogenesis. Frontiers in Biology 7(4): -

Both embryonic and adult neurogenesis involves the self-renewal/proliferation, survival, migration and lineage differentiation of neural stem/progenitor cells. Such dynamic process is tightly regulated by intrinsic and extrinsic factors and complex signaling pathways. Misregulated neurogenesis contributes much to a large range of neurodevelopmental defects and neurodegenerative diseases. The signaling of NFκB regulates many genes important in inflammation, immunity, cell survival and neural plasticity. During neurogenesis, NFκB signaling mediates the effect of numerous niche factors such as cytokines, chemokines, growth factors, extracellular matrix molecules, but also crosstalks with other signaling pathways such as Notch, Shh, Wnt/β-catenin. This review summarizes current progress on the NFκB signaling in all aspects of neurogenesis, focusing on the novel role of NFκB signaling in initiating early neural differentiation of neural stem cells and embryonic stem cells.

US$19.90

PMID: 24324484

DOI: 10.1007/s11515-012-1233-z


Other references

Del Bo', C.; Deon, V.; Campolo, J.; Lanti, C.; Parolini, M.; Porrini, M.; Klimis-Zacas, D.; Riso, P., 2017: A serving of blueberry (V. corymbosum) acutely improves peripheral arterial dysfunction in young smokers and non-smokers: two randomized, controlled, crossover pilot studies. Several studies have documented the important role of polyphenol-rich foods in the modulation of vascular remodelling and function. This study aimed to evaluate the capacity of a single portion of blueberry (V. corymbosum) to acutely improve perip...

Scott, D.; White, K., 1983: Demodicosis associated with systemic glucocorticoid therapy in two horses Demodex folliculorum var equi. Equine practice 5(4): 31-32

Agrell, I., 1952: Enzymes and cell differentiation in sponges. Arkiv for Zoologi, 3: 325-331

Leszczyszyn-Pynka, M., 2002: Clinical profile of infections caused by opportunistic microorganisms in HIV-positive patients--own observation. Przeglad Epidemiologiczny 55 Suppl 3: 109-116

Keeney, D.B.; Lagrue, Cément.; Bryan-Walker, K.; Khan, N.; Leung, T.L.F.; Poulin, R., 2008: The use of fluorescent fatty acid analogs as labels in trematode experimental infections. We examined the utility of fluorescent fatty acid analog dyes for labeling larval trematodes to use in experimental infections. Our goals were to identify two dyes that label larval trematodes belonging to the species <i>Maritrema novaezeala...

Urakawa Satoru; Kato Manabu, 1990: Stability of (Mg,Fe) (sub 14) Si (sub 5) O (sub 24) at 17 GPa and 1800 degrees C and its partitioning behavior of transition elements. Geophysical Research Letters 17(13): 2457-2460

Suneson, C.A.; Stevens, H., 1953: Studies with bulked hybrid populations of barley. Six composite crosses were grown for 6 to 24 generations. A continuous improvement in the yield level of the populations, and a non-random survival of characters in 4 linkage groups was observed. For breeders, this suggests the practicability of l...

D.G.ovanni Christian; Amiotte Suchet Philippe, 2003: Organic carbon released from carbonates and shales by chemical weathering; implications for the global organic carbon cycle understanding. We propose in this study an initial estimation of the annual organic matter yield induced by chemical weathering of carbonates and shales considering their global surface at outcrop and their organic matter content. The calculation also uses data...

Vignes, M.; Collingridge, G.L., 1997: The synaptic activation of kainate receptors. L-Glutamate, the principal excitatory neurotransmitter in the vertebrate central nervous system, acts on three classes of ionotropic glutamate receptors, named after the agonists AMPA, NMDA and kainate. AMPA receptors are known to mediate fast syn...

Cho, S.; Zhang, J., 2006: Ancient expansion of the ribonuclease A superfamily revealed by genomic analysis of placental and marsupial mammals. Members of the ribonuclease (RNase) A superfamily participate in a diverse array of biological processes, including digestion, angiogenesis, innate immunity, and possibly male reproduction. The superfamily is vertebrate-specific, with 13-20 highly...