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Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets


, : Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets. Clinical & Experimental Metastasis 29(7): 657-662

Therapies directed against VEGF-A and its receptors are effective in treating many mouse tumors but have been less so in treating human cancer patients. To elucidate the reasons that might be responsible for this difference in response, we investigated the nature of the blood vessels that appear in human and mouse cancers and the tumor surrogate blood vessels that develop in immunodeficient mice in response to an adenovirus expressing VEGF-A164. Both tumor and tumor surrogate blood vessels are heterogeneous and form by two distinct processes, angiogenesis and arterio-venogenesis. The first new angiogenic blood vessels to form are mother vessels (MV); MV arise from preexisting venules and capillaries and evolve over time into glomeruloid microvascular proliferations (GMP) and subsequently into capillaries and vascular malformations (VM). Arterio-venogenesis results from the remodeling and enlargement of preexisting arteries and veins, leading to the formation of feeder arteries (FA) and draining veins (DV) that supply and drain angiogenic vessels. Of these different blood vessel types, only the two that form first, MV and GMP, were highly responsive to anti-VEGF therapy, whereas late -formed capillaries, VM, FA and DV were relatively unresponsive. This finding may explain, at least in part, the relatively poor response of human cancers to anti-VEGF/VEGFR therapies, because human cancers, present for months or years prior to discovery, are expected to contain a large proportion of late-formed blood vessels. The future of anti-vascular cancer therapy may depend on finding new targets on late vessels, apart from those associated with the VEGF/VEGFR axis.

US$19.90

PMID: 22692562

DOI: 10.1007/s10585-012-9500-6


Other references

Svensek, D.; Zumer, S., 2003: Hydrodynamics of pair-annihilating disclinations in SmC films. The pair annihilation of smectic c-director defects with winding numbers +/-1 in a freestanding SmC film as a representative of the XY model is studied numerically, considering a full coupling of orientational degrees of freedom and hydrodynamics....

Leis, H.J.; Gleispach, H., 1989: Characterization of the antidiarrhoeal loperamide by gas chromatography-mass spectrometry and application of the Hofmann degradation and Cope elimination reaction. Journal of Chromatography 494: 324-330

Schober, K.E.; Kaufhold, J.; Kipar, A., 2000: Mitral valve dysplasia in a foal. Equine Veterinary Journal 32(2): 170-173

Barroga, Edward F., 2000: A study on the differentiation therapy of canine osteosarcoma with vitamin D and retinoids. Japanese Journal of Veterinary Research 48(1): 47-48, May

Moore, G.T.; Kraemer, H.; Pennington, M.E.; Quick, A.M.; Marlatt, C.L.; Wiley, H.W.; Leighton, M.O.; Doty, A.H., 1905: The Use Of Copper In The Purification Of Water Supplies. Science 21(538): 603-624

Novakova, J.; Krizova, H.; Matousek, V.; Dvorak, J., 1999: Vliv genotypu RYR1 na plodnost prasnic presticke cernostrakate (Pc) ve vybranych slechtitelskych chovech. The genotype RYR1 was found out in sows of Pc breed. 96 sows were included in the test. Influence of genotype RYR1 was performed on the fertility. The frequencies of RYR1 genotype were: N/N = 84,38%, N/n = 15,62%. Frequency of the allele N was: N...

Hatley R.H.M.; Franks F., 1988: Low temperature induced denaturation of lactate dehydrogenase ldh at physiological ph. Cryobiology 25(6): 538-539

Bundza, A.; Greig, A.S.; Speckmann, G.W., 1979: Case report: osteolytic osteosarcoma in a German Shepherd bitch. Necropsy of a six year old female German Shepherd revealed the presence of a large oval mass in the thoracic cavity originating from the thickened proximal portion of the right fourth rib. Osteolytic osteosarcoma was diagnosed on the basis of gros...

Glimet, T.; Masse, J.P.; Ryckewaert, A., 1980: Radiologic study of painless knees in 50 men over 65 years of age 1. tele radiography in the frontal position with the patient standing. Teleradiographic examinations of the lower limb, from the frontal position with the patient standing, were conducted in 50 men over 65 yr of age who never had painful knees. One knee (of 100) had an internal femoro-tibial arthrosis. The femoro-tib...

Eldridge, K.G., 1957: Significance of Diplodia pinea in plantations. Summarizes part of a thesis on D. pinea, with particular reference to the question of its status as a pest of Pines in Europe and Australia.