geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus


, : β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus. European Journal of Neuroscience 36(4): 2461-2469

Integrins play key roles in the developing and mature nervous system, from promoting neuronal process outgrowth to facilitating synaptic plasticity. Recently, in hippocampal pyramidal neurons, ?3 integrin (ITG?3) was shown to stabilise synaptic AMPA receptors (AMPARs) and to be required for homeostatic scaling of AMPARs elicited by chronic activity suppression. To probe the physiological function for ITG?3-dependent processes in the brain, we examined whether the loss of ITG?3 affected fear-related behaviours in mice. ITG?3-knockout (KO) mice showed normal conditioned fear responses that were similar to those of control wild-type mice. However, anxiety-like behaviour appeared substantially compromised and could be reversed to control levels by lentivirus-mediated re-expression of ITG?3 bilaterally in the ventral hippocampus. In hippocampal slices, the loss of ITG?3 activity did not compromise Hebbian forms of plasticity neither acute pharmacological disruption of ITG?3 ligand interactions nor genetic deletion of ITG?3 altered long-term potentiation (LTP) or long-term depression (LTD). Moreover, we did not detect any changes in short-term synaptic plasticity upon loss of ITG?3 activity. In contrast, acutely disrupting ITG?1 ligand interactions or genetic deletion of ITG?1 selectively interfered with LTP stabilisation whereas LTD remained unaltered. These findings indicate a lack of requirement for ITG?3 in the two robust forms of hippocampal long-term synaptic plasticity, LTP and LTD, and suggest differential roles for ITG?1 and ITG?3 in supporting hippocampal circuit functions.In rodent hippocampal pyramidal neurons, ?3 integrin regulates synaptic AMPA receptors and is required for homeostatic plasticity. Here we find that the loss of ?3 integrin activity is dispensable for conditioned fear behaviour in mice and for LTP and LTD in acute hippocampal slices, which is in contrast to the loss of ?1 integrin that compromises LTP but not LTD. Our findings highlight differential roles for ?3 and ?1 integrins in supporting hippocampal circuit functions.

US$19.90

PMID: 22748100

DOI: 10.1111/j.1460-9568.2012.08163.x


Other references

Saad, E.; Curtolo Barros, L.; Biscola, N.; Pimenta, D.C.; Barraviera, S.R.C.S.; Barraviera, B.; Seabra Ferreira, R., 2012: Intraspecific variation of biological activities in venoms from wild and captive Bothrops jararaca. The venom of Bothrops jararaca is composed of complex mixture of molecules, mainly lectins, metalloproteinases, serinoproteinases, desintegrins, phospholipases, and peptides. This composition may vary according to the snake's age, gender, and...

Stoolman L.M.; Ebling H., 1990: Regulation of the human endothelial binding lectin lec cam in peripheral blood lymphocytes and cultured t lymphoblasts. FASEB Journal 4(4): A911

Fenley, A.T.; Henriksen, N.M.; Muddana, H.S.; Gilson, M.K., 2014: Bridging Calorimetry and Simulation through Precise Calculations of Cucurbituril-Guest Binding Enthalpies. We used microsecond time scale molecular dynamics simulations to compute, at high precision, binding enthalpies for cucurbit[7]uril (CB7) with eight guests in aqueous solution. The results correlate well with experimental data from previously publ...

Ohta, Y.; Ochiai, K.; Suzuki, T.; Chiba, A.; Chichibu, S., 1998: Segregation of a colony of congenitally hydrocephalic rat. Neuroscience Research Supplement (22): S340

Elliott, Ml, 2001: Disease management: its not just fungicides!. Turf grass trends 10(4): 1-5

Wendorf F.; Schild R.; Said R., 1970: Problems of dating the late Paleolithic in Egypt. Nobel Symposium Pages 57-79

Venkatesan, M.I.; Merino, O.; Baek, J.; Northrup, T.; Sheng, Y.; Shisko, J., 2010: Trace organic contaminants and their sources in surface sediments of Santa Monica Bay, California, USA. Spatial distribution of selected contaminants in the surface sediments of Santa Monica Bay (SMB), California was investigated. Sediments were analyzed for DDTs (DDT and metabolites), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbo...

Cheslack-Postava, K.; Fallin, M.D.; Avramopoulos, D.; Connors, S.L.; Zimmerman, A.W.; Eberhart, C.G.; Newschaffer, C.J., 2007: beta2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort. The beta(2)-adrenergic receptor is part of the catecholamine system, and variants at two polymorphic sites in the gene coding for the receptor (ADRB2) confer increased activity. Overstimulation of this receptor may alter brain development, and ha...

Kim, K-Hong.; Brown, K.M.; Harris, P.V.; Langston, J.A.; Cherry, J.R., 2007: A proteomics strategy to discover beta-glucosidases from Aspergillus fumigatus with two-dimensional page in-gel activity assay and tandem mass spectrometry. Economically competitive production of ethanol from lignocellulosic biomass by enzymatic hydrolysis and fermentation is currently limited, in part, by the relatively high cost and low efficiency of the enzymes required to hydrolyze cellulose to fe...

Gil, M.C.; Hermoso de Mendoza, M.; Rey, J.; Alonso, J.M.; Poveda, J.B.; Hermoso de Mendoza, J., 1999: Aetiology of caprine contagious agalactia syndrome in Extremadura, Spain. Between 1991 and 1995, 596 adult and young goats, from 43 flocks affected by contagious agalactia (CA) outbreaks in Extremadura, were sampled. 1309 samples were collected from live and dead goats. 543 isolates were obtained showing colonies typica...