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Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)

, : Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Annals of Oncology 23(7): 1880-1888

To evaluate the dose–response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. We analyzed data from 12 case–control studies within the International Pancreatic Cancer Case–Control Consortium (PanC4), including 657 pancreatic cases and 12 89 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the OR was 1.2 (95% confidence interval 1.–1.3) for former smokers and 2.2 (95% CI 1.7–2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR = 3.4 for ≥35 cigarettes per day, P for trend <.1). Risk increased in relation to duration of cigarette smoking up to 4 years of smoking (OR = 2.4). No trend in risk was observed for age at starting cigarette smoking, whereas risk decreased with increasing time since cigarette cessation, the OR being .98 after 2 years. This uniquely large pooled analysis confirms that current cigarette smoking is associated with a twofold increased risk of pancreatic cancer and that the risk increases with the number of cigarettes smoked and duration of smoking. Risk of pancreatic cancer reaches the level of never smokers ~2 years after quitting.


PMID: 22104574

DOI: 10.1093/annonc/mdr541

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Odland, L.M.; Macdougall, J.D.; Tarnopolsky, M.; Elorriaga, A.; Borgmann, A.; Atkinson, S., 1994: The effect of oral Cr supplementation on muscle and power output during a short-term maximal cycling task. Medicine & Science in Sports & Exercise 26(5 SUPPL ): S23

Shoba S.A.; Ammosova Y.M., 1974: Study of the humus of secondary podzolic soils of western siberia. Biologicheskie Nauki (Moscow) 17(1): 123-129

Penny, R.; Vecsei, P., 1989: Congenital adrenal hyperplasia due to combined 21- and 11 beta-hydroxylase deficiency. A 26-day-old male was evaluated because on routine follow-up visit his weight was noted to be 3292 g which was not a significant weight gain over his birth weight of 3178 g. His serum electrolytes (NA 107 meq/1, K 8.0 meq/1, Cl 82 meq/1, and HCO2...

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Neumann, M.; Marienfeld, R.; Serfling, E., 1997: Rel/NF-kappaB transcription factors and cancer: Oncogenesis by dysregulated transcription (Review). The transcription factors of the Rel/NF-kappaB family play a central role in immune regulation. In addition, they may be involved in the pathogenesis of certain tumors, especially those of hematopoietic origin. In this review evidence is summarize...

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