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Effect of a somatostatin infusion on circulating levels of adipokines in obese women

, : Effect of a somatostatin infusion on circulating levels of adipokines in obese women. Metabolism: Clinical and Experimental 61(12): 1797-1802

Changes in circulating levels of many adipocyte-derived peptides, including adipokines such as adiponectin, leptin and tumor necrosis factor alpha (TNF-?), have been reported in obesity (OB). Somatostatin (SRIF) inhibits circulating levels of adiponectin and leptin in lean (LN) subjects, but the effect of a SRIF infusion on these adipokines, including TNF-?, in OB is to date unknown. Ten young women (5 OB and 5 LN) were studied. All subjects underwent an infusion of SRIF (9 ?g/kg/h i.v., over 6 min), with blood samples drawn prior to and at different time intervals after SRIF administration. Plasma levels of adiponectin, leptin and TNF-? were measured at each interval. Basal levels of leptin and TNF-? were significantly higher in OB than LN women, whereas levels of adiponectin were significantly lower in OB than LN subjects. SRIF significantly inhibited plasma concentrations of adiponectin (at 6 min) in both OB and LN women, without affecting those of leptin and TNF-? in either group. In LN subjects, the inhibitory effect of SRIF on plasma adiponectin persisted up to 15 min, whereas SRIF infusion withdrawal in OB women resulted in a prompt restoration of basal levels of the adipokine. Plasma concentrations of leptin and TNF-?, which are higher in OB than LN subjects, are unaffected by a SRIF infusion, which, in contrast, inhibits circulating levels of adiponectin in both groups, with a delayed return to the baseline secretion of the adipokine in LN subjects.


PMID: 22784430

DOI: 10.1016/j.metabol.2012.05.019

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