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Bcl-2, Bcl-6, and IPI are prognostic indicators in patients with DLBCL treated with rituximab-containing chemotherapy

, : Bcl-2, Bcl-6, and IPI are prognostic indicators in patients with DLBCL treated with rituximab-containing chemotherapy.

This study aimed to clarify the clinicopathological prognostic parameters of de novo diffuse large B-cell lymphoma (DLBCL) in the rituximab era. We examined the correlation of 22 clinicopathological parameters with progression-free survival (PFS), overall survival (OS), and primary refractory disease in 285 DLBCL patients treated with rituximab-containing chemotherapy. Complete response rate was 87%, overall response rate was 91%, 5-year PFS rate was 72%, and 5-year OS rate was 91%. By log-rank test, higher International Prognostic Index (IPI) (P < .1), Bcl-2 positivity (P = .13), Bcl-6 negativity (P = .112), and no irradiation (P = .371) were significantly correlated with shorter PFS; higher IPI (P = .17), starry sky pattern (P = .466), and no irradiation (P = .264) correlated with shorter OS. In multivariate analyses, higher IPI (P = .6), Bcl-2 positivity (P = .15), and Bcl-6 negativity (P = .4) were significantly correlated with shorter PFS; higher IPI (P = .45) correlated with shorter OS. Bcl-2 (P = .29), Bcl-6 (P = .2), and IPI (P < .1) were significantly correlated with primary refractory disease. In conclusion, Bcl-2 positivity, Bcl-6 negativity, and higher IPI were indicators of shorter PFS and OS plus primary refractory disease in patients with DLBCL in the rituximab era.


DOI: 10.1111/j.1349-7006.2012.02382.x

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