+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis

, : Disease characteristics and clinical outcome in young adults with essential thrombocythemia versus early/prefibrotic primary myelofibrosis. Blood 120(3): 569-571

In the present study, we investigated disease characteristics and clinical outcome in young patients (< 4 years) with World Health Organization (WHO)–defined essential thrombocythemia (ET) compared with early/prefibrotic primary myelofibrosis (PMF) with presenting thrombocythemia. We recruited 213 young patients (median age, 33.6 years), ncluding 178 patients (84%) with WHO-defined ET and 35 patients (16%) showing early PMF. Median follow-up time was 7.5 years. A trend for more overall thrombotic complications, particularly arterial, was seen in early PMF compared with ET. Progression to overt myelofibrosis was 3% in ET and 9% in early PMF, but no transformation into acute leukemia was observed. Combining all adverse events (thrombosis, bleeding, and myelofibrosis), the rate was significantly different (1.29% vs 3.43% of patients/year, P = .1) in WHO-ET and early PMF, respectively. In multivariate analysis, early PMF and the JAK2V617F mutation emerged as independent factors predicting cumulative adverse events.


PMID: 22700720

DOI: 10.1182/blood-2012-01-407981

Other references

Tanada, M.U.hida, H.S.wa, K., 1973: Studies on noodles. IV. Colorim. Journal of the Food Hygienic Society of Japan: 14 (5) 431-436

Kawabe, A.; Nasu, Y., 1994: A revision of the genus Gibberifera Obraztsov (Lepidoptera: Tortricidae), with descriptions of four new species. Tyo To Ga e 30; 45(2): 79-96

Zhao, D.K.; Xu, H.Q.; Liu, J.S., 1990: Main pharmacological roles and clinical curative effect of sanbi rebao. Sanbi Rebao (contain 32 components, such as Radix Aconiti, Rhizoma Chuanxiong, Semen Strychni, Radix Glycyrrhizae, Radix Angelicae sinensis, Radix Ledebouriellae, Fructus Evodiae, borneolum syntheticum, etc.) had antagonistic action on the ear swo...

Kienitz, M., 1967: On the antibiotic treatment of acute enteritis in children. Arzneimittel-Forschung 17(11): 1400-1402

Graham, M.F.; Willey, A.; Zhu, Y.N.n; Yager, D.R.; Sugerman, H.J.; Diegelmann, R.F., 1997: Corticosteroids repress the interleukin 1beta-induced secretion of collagenase in human intestinal smooth muscle cells. Background and Aims: The cytokine interleukin (IL)-1beta induces collagenase expression and inhibits collagen expression in human intestinal smooth muscle (HISM) cells. Corticosteroids cause transrepression of certain genes, including the collagen...

Ullrey, D.E.; Youatt, W.G.; Johnson, H.E.; Cowan, A.B.; Covert, R.L. : Magee, W.T., 1972: Digestibility and estimated metabolizability of aspen browse for white-tailed deer. 24 pregnant white-tailed deer (Odocoileus virginianus) were used to determine the apparent digestibility and to estimate the apparent metabolizability of winter browse from Thuja occidentalis and Populus grandidentata. 8 deer were fed T. occidenta...

Das, P.; Paik, D.; Naskar, K.; Chakraborti, T., 2017: Leishmania donovani serine protease encapsulated in liposome elicits protective immunity in experimental visceral leishmaniasis. This study is aimed to evaluate the protective effect of L. donovani intracellular serine protease (SP-Ld) in combination with Freund's adjuvant and liposomal formulations against experimental visceral leishmaniasis (VL). The animals were imm...

Chilton N.B.; Bull C.M., 1991: A comparison of the reproductive parameters of females of two reptile tick species. In comparisons of females of two reptile tick species Aponomma hydrosauri and Amblyomma limbatum, Ap. hydrosauri was initially larger, and after mating on the host engorged faster and remained attached for a shorter time before completing engorgem...

Boden, G.; Essa, N.; Owen, O.E., 1975: Effects of intraduodenal amino acids, fatty acids, and sugars on secretin concentrations. Animals were 21 healthy dogs of bodyweight 15 to 20 kg starved overnight. Solutions infused into the duodenum were: an 8.5% solution of free amino acids containing 8 essential and 7 nonessential amino acids; sodium oleate 50 mmoles/litre; a micell...

Friedman, J.H.; Hader, M.; Dutchen, W.; Bressler, D.M., 1965: The Prognosis Of The Psychoneuroses In Younger Adults As Predicated From A Geriatric Mental Hygiene Clinic. Of 293 patients admitted for depression over a 3-yr. period to a geriatric mental hygiene clinic, none had suffered from a previous psychoneu-rotic state. Fifty-six patients suffered previous episodes of depressed states, varying from 1 to 3 attac...