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Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis

, : Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. Journal of Infectious Diseases 206(4): 606-616

Secondary hospital-acquired fungal infections are common in critically-ill patients and mortality remains high despite antimicrobial therapy. Interleukin-7 (IL-7) is a potent immunotherapeutic agent that improves host immunity and has shown efficacy in bacterial and viral models of infection. This study examined the ability of IL-7, which is currently in multiple clinical trials (including hepatitis and human immunodeficiency virus), to improve survival in a clinically relevant 2-hit model of fungal sepsis. Mice underwent cecal ligation and puncture to induce peritonitis. Four days later, surviving mice had intravenous injection with Candida albicans. Following Candida infection, mice were treated with IL-7 or saline control. The effect of IL-7 on host immunity and survival was recorded. IL-7 ameliorated the loss of immune effector cells and increased lymphocyte functions, including activation, proliferation, expression of adhesion molecules, and interferon- production. These beneficial effects of IL-7 were associated with an increase in global immunity as reflected by an enhanced delayed type hypersensitivity response and a 1.7-fold improvement in survival. The present findings showing that IL-7 improves survival in fungal sepsis, together with its previously reported efficacy in bacterial and viral infectious models, further supports its use as a novel immunotherapeutic in sepsis.


PMID: 22693226

DOI: 10.1093/infdis/jis383

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Yeki, M.; Koda, M.; Matono, T.; Sugihara, T.; Maeda, K.; Murawaki, Y., 2009: Preventative and therapeutic effects of perindopril on hepatic fibrosis induced by bile duct ligation in rats. The aim of this study was to examine the preventative and therapeutic effects of an angiotensin-converting enzyme inhibitor, perindopril, on cholestasis-induced liver fibrosis. Perindopril was administered orally for 21 days immediately after bile...

Woods, D.W.; Marcks, B.A., 2005: Controlled evaluation of an educational intervention used to modify peer attitudes and behavior toward persons with Tourette's Syndrome. Individuals who exhibit motor and vocal tics are viewed as less socially acceptable than persons who do not exhibit tics. Efforts have been made to alter the negative perceptions through the use of education. However, the effectiveness of peer edu...

Sharaev, P.N.; Bogdanov, N.G.; Butolin, E.G., 1977: Antagonism in the effect of sodium salicylate and of vikasol on the gastric wall. Content of all the biopolymers containing hexosamine, acidic mucopolysaccharides and glucoproteins was decreased in rat gastric wall after administration of sodium salicylate. Administration of vikasol did not affect the content of these substance...

Mariam, M.A.; Douressamy, S.; Chandramohan, N., 2000: New hosts of spiralling whitefly (SWF) Aleurodicus dispersus Russell (Homoptera: Aleyrodidae). Eleven new hosts of Aleurodicus dispersus are recorded from Coimbatore, India. Among them are Leucas aspera, Trianthema portulacastrum, Datura metel and Pedilanthus sp.

Angstadt, C.N.; Nieman, L.Z.; Morahan, P.S., 1998: Strategies to expand the definition of scholarship for the health professions. Standards for promotions and tenure for health professions faculty must require the same intellectual and methodologic rigor as those in other academic areas. The challenge is to expand the traditional view of scholarship as research to include sc...

Nakagome Y.; Abe T., 1983: The loss of kinetochores from chromosomes of aged individuals. Japanese Journal of Human Genetics 28(2): 164

Smith, Luther, 1942: Cytogenetics of a factor for multiploid sporo-cytes in barley. A recessive factor in barley ([image] = 7) is described which disturbs the process of meiosis, resulting in pollen mother cell masses with < 7 to > 100 pairs of chromosomes at 1st metaphase. The explanation favored is that the walls of the p...

Miki, I.; Yoshikawa, S.; Takada, S.; Fujita, T.; Morii, H., 1963: A case of primary hyperparathyroidism with parathyroid hormone assay in urine and adenoma tissue. A 42 year old male complained of limping and pain in the left leg, where a bone tumor was demonstrated by X-ray. Serum calcium was 11.2 to 15.2 mg%, serum P 1.5 to 1.9 mg%, and serum alkaline phosphatase 8.7-10.4 Bessy- Lowry units. A markedly neg...

Nath K.A.; Croatt A.J., 1989: Hydrogen peroxide impairs glomerular and tubular function through an iron dependent mechanism. Clinical Research 37(4): 923A

Anonymous, 1986: Cataract surgery in developing countries. Tropical Doctor 16(1): 24-25