geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols


, : Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols. Bmc Oral Health 12: 22-22

Over the past decade, advances in the field of cancer treatments have been counterbalanced by a rising number of immunosuppressed patients with a multitude of new risk factors for infection. Hence, the aim of this study was to determine risk factors, infectious pathogens in blood and oral cavity of oral cancer patients undergoing different treatment procedures. The present prospective cohort analysis was conducted on the patients undergoing treatment in the radiotherapy unit of Regional Cancer Institute, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, during the period of January 27 to October 29. Total 186 patients with squamous cell carcinoma of oral cavity were analyzed in the study. Based on treatment procedures patients were divided into three groups, group I were under radiotherapy, group II under chemotherapy and group III were of radio chemotherapy together. Clinical isolates from blood and oral cavity were identified by following general microbiological, staining and biochemical methods. The absolute neutrophile counts were done by following the standard methods. Prevalent bacterial pathogens isolated were Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, Pseudomonas aeruginosa, Klebsiella pneumonia, Proteus mirabilis, Proteus vulgaris and the fungal pathogens were Candida albicans, Aspergillus fumigatus. The predominant gram negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumonia were isolated from blood of radiotherapy and oral cavity of chemotherapy treated cases respectively. The predominance of gram positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis) were observed in blood of chemotherapy, radio chemotherapy cases and oral cavity of radiotherapy, radio chemotherapy treated cases. Our study also revealed the presence of C. albicans fungi as most significant oral cavity pathogens in radiotherapy and radio chemotherapy cases.Gram positive bacteria and Gram negative were reported from the blood of all the three groups' patients. Oral mucositis played a significant role in oral cavity infection and make patients more prone to C. albicans infection.

US$19.90

PMID: 22817766

DOI: 10.1186/1472-6831-12-22


Other references

Togashi K.; Nishimura K.; Nakano Y.; Itoh H.; Torizuka K.; Ozasa H.; Watanabe T., 1986: Cystic pedunculated leiomyomas of the uterus with unusual computed tomographic manifestations. Two cases of pedunculated, cystic uterine leiomyoma with unusual CT manifestations are described. The normal contours of the uterus were largely preserved. Ascites and pleural effusion were noted in one case.

Merlo, G.R.; Venesio, T.; Bernardi, A.; Cropp, C.S.; Diella, F.; Cappa, A.P.M.; Callahan, R.; Liscia, D.S., 1994: Evidence for a second tumor suppressor gene on 17p linked to high S-phase index in primary human breast carcinomas. The short area of chromosome 17 is a frequent target for deletions in human tumors, including breast cancer. We have investigated by restriction fragment polymorphism analysis the pattern of loss of heterozygosity (LOH) at four loci on 17p13.1-17p...

Feher, D., 1934: Experimentelle Untersuchungen uber die mikrobiologischen Grundlagen der Schwankun-gen der Bodenaziditat II. The influence of differences in moisture content of forest soils on pH was determined. The principal changes in the pH of the soils during the year were found to be due to biological factors and not to physico-chemical influences. The pH of steril...

Kinne, R.; Kinne-Saffran, E., 1969: Isolation and enzymatic characterization of a brushborder fraction from rat kidney. Pflugers Archiv 308(1): 1-15

Dasgupta, S.; Dey, S.; Choudhury, S.; Mazumder, B., 2013: Topical delivery of aceclofenac as nanoemulsion comprising excipients having optimum emulsification capabilities: preparation, characterization and in vivo evaluation. The aim of the present study was to investigate the potential of a nanoemulsion for topical delivery of aceclofenac using different excipients having optimum emulsifying ability rather than their solubilizing capacity. The oil-in-water nanoemulsio...

Graham, L.; Neal, C.P.; Garcea, G.; Lloyd, D.M.; Robertson, G.S.; Sutton, C.D., 2012: Evaluation of nurse-led discharge following laparoscopic surgery. The United Kingdom's Department of Health has identified reducing delays in patient discharge as a key aim for Health Service development. Laparoscopic cholecystectomy and laparoscopic inguinal hernia repair may be safely performed on a short...

Thompson, J.S.; Duckworth, W.C., 2001: Insulin pumps and glucose regulation. With recent technologic advances there has been a resurgence of interest in implantable insulin infusion devices. A satisfactory closed loop system has been elusive. Open loop systems include the pump, delivery catheter, and patient pump communica...

Soc Med Hyg Trav Strasbourg, 1967: Meeting of the societe de medecine et d hygiene du travail de strasbourg strasbourg society for industrial hygiene and medicine april 15 1967. Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale 28(12): 867-875

Anonymous, 1977: Inflammatory diseases of the female genitalia, their diagnosis and treatment. Inflammations in the region of portio. Fortschritte der Medizin 95(27): 1726-1727

Kucyniak, James, 1960: An unusual association of bryophytes in Charlevoix County, Quebec. A collection of 20 specimens made in an interesting geological area on the north shore of the St. Lawrence River where limestone of the Middle Ordovician comes abruptly in contact with Precambrian granite, affords the author the opportunity to com...