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Antioxidant potential of zinc-flavonol complex studied in streptozotocin induced experimental diabetes in rats

, : Antioxidant potential of zinc-flavonol complex studied in streptozotocin induced experimental diabetes in rats.

Diabetic oxidative stress coexists with a reduction in the antioxidant status, which can further increase the deleterious effects. Zinc is an essential trace element with significant antidiabetic activity. However, the acceptance of zinc compounds as promising therapeutic antidiabetic agents has been slowed due to the concern for chronic toxicity. Recently, we have designed, synthesized and characterized a novel Zinc-flavonol complex and evaluated its antidiabetic efficacy in streptozotocin induced experimental diabetes in rats. The present study was aimed to evaluate the role of zinc-flavonol complex on antioxidant status in diabetic rats. Experimental diabetes was induced in rats by streptozotocin intraperitoneally and then diabetic rats were treated with Zinc-flavonol complex (5 mg/kg body weight) for a period of 3 days. The extent of oxidative stress was assessed by determining the levels of lipid peroxides, activities of enzymatic antioxidants in the pancreatic tissues and the levels of non enzymatic antioxidants in plasma. The nuclear levels of NF-?B p65, nitric oxide, TNF-?, IL-1? and IL-6 levels were determined. Histological observations were performed on pancreatic tissues. The antioxidant levels were significantly improved in addition to significant alleviation in the levels of oxidative stress markers upon oral treatment with zinc-flavonol complex. The nuclear levels of NF-?B p65, nitric oxide, TNF-?, IL-1? and IL-6 levels were found to be significantly altered. Histological observations evidenced that zinc-flavonol effectively protects the pancreatic ?-cells from oxidative damage. The results of the present study indicate that the zinc-flavonol complex possess antioxidative and anti-inflammatory role in diabetic milieu.The significant finding of the study: Zinc-flavonol complex protects the pancreatic beta cells from hyperglycemia mediated oxidative damage.This study adds: Based on the observed data the zinc-flavonol complex possesses significant antidiabetic property without any adverse effects in the experimental diabetic rats.


DOI: 10.1111/j.1753-0407.2012.00226.x

Other references

Kawabata, H., 2017: The mechanisms of systemic iron homeostasis and etiology, diagnosis, and treatment of hereditary hemochromatosis. Hereditary hemochromatosis (HH) is a group of genetic iron overload disorders that manifest with various symptoms, including hepatic dysfunction, diabetes, and cardiomyopathy. Classic HH type 1, which is common in Caucasians, is caused by bi-alle...

Yang, Q.; Sang, P.; Liu, S-Qun., 2015: 155 The role of solvent mobility in protein dynamics. Journal of Biomolecular Structure & Dynamics 33 Suppl 1: 100-101

Kawabe, K., 1997: Indigocarmine test. Nihon Rinsho. Japanese Journal of Clinical Medicine 55 Suppl 2: 608-609

Hamm, J., 1971: Clinical aspects of lung diseases due to air pollution. Praxis der Pneumologie 25(8): 453-465

Wong, A.K.F.; Howie, J.; Petrie, J.R.; Lang, C.C., 2009: AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. AMPK (AMP-activated protein kinase) is a heterotrimetric enzyme that is expressed in many tissues, including the heart and vasculature, and plays a central role in the regulation of energy homoeostasis. It is activated in response to stresses that...

Koebmann, B., J.; Westerhoff, H., V.; Snoep, J., L.; Solem, C.; Pedersen, M., B.; Nilsson, D.; Michelsen, O.; Jensen, P., R., 2002: The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth. Using molecular genetics we have introduced uncoupled ATPase activity in two different bacterial species, Escherichia coli and Lactococcus lactis, and determined the elasticities of the growth rate and glycolytic flux towards the intracellular [AT...

Casgrain, G.; Léger, J.; Léger, F., 1965: A slowly absorbed pollen extract: follow-up of a clinical study. L'union Medicale du Canada 94(6): 808-810

Falconi, M.; O'Neill, P.; Stroppolo, M.Elena.; Desideri, A., 2002: Superoxide dismutase kinetics. Methods in Enzymology 349: 38-49

Naĭkhin, A.N.; Topuriia, N.V.; Ismagulov, A.T.; Denisov, G.M.; Tsaritsyna, I.M., 1981: Complex study of population immunity to 3 influenza A virus antigens. In 5 large cities of the USSR a four-year study of the population immunity to 3 antigens of influenza A virus (hemagglutinin, neuraminidase and ribonucleoprotein antigens) was carried out. The time course of immunity to these antigens had a simila...

Putila-Mäntylä; Graeffe, 1987: High-resolution L x-ray spectrum of In. Physical Review. A, General Physics 35(2): 673-678