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Antioxidant potential of zinc-flavonol complex studied in streptozotocin induced experimental diabetes in rats


, : Antioxidant potential of zinc-flavonol complex studied in streptozotocin induced experimental diabetes in rats.

Diabetic oxidative stress coexists with a reduction in the antioxidant status, which can further increase the deleterious effects. Zinc is an essential trace element with significant antidiabetic activity. However, the acceptance of zinc compounds as promising therapeutic antidiabetic agents has been slowed due to the concern for chronic toxicity. Recently, we have designed, synthesized and characterized a novel Zinc-flavonol complex and evaluated its antidiabetic efficacy in streptozotocin induced experimental diabetes in rats. The present study was aimed to evaluate the role of zinc-flavonol complex on antioxidant status in diabetic rats. Experimental diabetes was induced in rats by streptozotocin intraperitoneally and then diabetic rats were treated with Zinc-flavonol complex (5 mg/kg body weight) for a period of 3 days. The extent of oxidative stress was assessed by determining the levels of lipid peroxides, activities of enzymatic antioxidants in the pancreatic tissues and the levels of non enzymatic antioxidants in plasma. The nuclear levels of NF-?B p65, nitric oxide, TNF-?, IL-1? and IL-6 levels were determined. Histological observations were performed on pancreatic tissues. The antioxidant levels were significantly improved in addition to significant alleviation in the levels of oxidative stress markers upon oral treatment with zinc-flavonol complex. The nuclear levels of NF-?B p65, nitric oxide, TNF-?, IL-1? and IL-6 levels were found to be significantly altered. Histological observations evidenced that zinc-flavonol effectively protects the pancreatic ?-cells from oxidative damage. The results of the present study indicate that the zinc-flavonol complex possess antioxidative and anti-inflammatory role in diabetic milieu.The significant finding of the study: Zinc-flavonol complex protects the pancreatic beta cells from hyperglycemia mediated oxidative damage.This study adds: Based on the observed data the zinc-flavonol complex possesses significant antidiabetic property without any adverse effects in the experimental diabetic rats.

US$19.90

DOI: 10.1111/j.1753-0407.2012.00226.x


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