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The combination of RAD1 and NVP-BKM12 synergistically inhibits the growth of lung cancer in vitro and in vivo


, : The combination of RAD1 and NVP-BKM12 synergistically inhibits the growth of lung cancer in vitro and in vivo.

This study focuses on determining whether the combination of NYP-BKM120 (BKM120) and RAD001 exerts enhanced therapeutic effect against lung cancer. The combination of BKM120 and RAD001 exerted synergistic inhibitory effects on the growth of lung cancer cells both in culture and in mouse xenograft model. This combination abrogated RAD001-induced Akt phosphorylation and exerted enhanced suppressive effect on 4EBP1 phosphorylation. Collectively, we suggest that the combination of RAD001 and BKM120 may be an effective regimen for treatment of lung cancer, hence warranting further evaluation of the combination in the clinic. RAD001 and NVP-BKM120 combination synergistically inhibit the growth of lung cancer. The combination exerts enhanced effects on p21 upregulation and G1 arrest. The combination enhances suppression of p-4EBP1 without elevation of Akt phosphorylation.

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