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Serum biomarkers in type 2 diabetic patients with non-alcoholic steatohepatitis and advanced fibrosis


, : Serum biomarkers in type 2 diabetic patients with non-alcoholic steatohepatitis and advanced fibrosis. Hepatology Research 43(5): 508-515

Advanced stages of non-alcoholic fatty liver disease (NAFLD) are highly prevalent in type 2 diabetes (T2DM), however no diabetes-related or biochemical variable seems to be predictive of severity of NAFLD. The aim was to investigate the association of several serum biomarkers with the more severe histopathological stages of NAFLD in T2DM. In a cross-sectional design, 84 T2DM patients with biopsy-proven NAFLD had adiponectin, TNF-?, TGF-?1, interleukins 6, 8 and 10 and C-reactive protein measured. NAFLD severity was evaluated by two hepatopathologists according to the non-alcoholic steatohepatitis (NASH) Clinical Research Network scoring system. Independent associations of cytokines with NASH and advanced fibrosis were evaluated by multivariate logistic regressions. Sixty-six patients (78.6%) had NASH, and 52 patients (61.9%) had advanced fibrosis considering the highest score between the 2 pathologists. Patients with NASH or with advanced fibrosis had equal cytokine levels than those without NASH or with absent/light fibrosis, except for a lower serum adiponectin (8.59 vs 12.77 ?g/ml; p=0.015) in patients with NASH, and a lower TGF-?1 (170 vs 180 pg/ml; p=0.026) in patients with advanced fibrosis. In multivariate analysis, lower adiponectin was independently associated with NASH (odds ratio: 7.7, 95%CI: 1.5-39.9, p=0.014, for the subgroup with adiponectin below the median value), whereas both lower adiponectin and lower TGF-?1 levels were associated with advanced fibrosis. Low adiponectin and low TGF-?1 are associated with severest NAFLD stages in T2DM and might be a valuable tool to support liver biopsy indication in this setting.

US$19.90

PMID: 23067270

DOI: 10.1111/j.1872-034X.2012.01106.x


Other references

Koch, R., 2001: Stable chimney extensions - assessing wide angle nozzles, diffusers and chimney extensions. The importance of the adhering to appropriate ventilation technology guidelines when planning chimney extensions, including wide angle nozzles and diffusers, for stables to comply with environmental emmission standards is discussed. Misjudgements...

Geetha, N.; Gopalan, M., 1997: Prey preference of Cyrtorhinus lividipennis Reuter (Heteroptera, Miridae) among three species of rice hoppers. Prey preference of third and fifth instars and adult predatory mirids Cyrtorhinus lividipennis, for rice hoppers, Nilaparvata lugens, Sogatella furcifera and Nephotettix sp. was studied under glasshouse conditions. Mirid nymphs and adults preferre...

Heap, R.B.; Robinson, D.W.; Lamming, G.E., 1962: The relationship between ovarian hormones and uterine infection in the rabbit. A possible mode of action. The effect of ovarian hormones on the resistance of rabbits to experimental uterine infection was compared in estrous and pseudo-pregnant animals and in ovariectomized rabbits treated with estradiol (10 [mu]g./day for 3 days) or progesterone (5 mg...

Carson M.L., 1987: Assessment of six models of host pathogen interaction in horizontal pathosystems. The following six genetic models of host-pathogen interaction in horizontal pathosystems were evaluated: the interaction for resistance, interaction for susceptibility, Parlevliet and Zadok's addition, Fleming and Person's additive, Flem...

Park S.C.; Yang J.H.; Koh S.H.; Kim S.T.; Lee J.B., 1985: Estradiol dependency of tumor growth levels of steroid receptor contents and enzymic activities in rat breast cancer tissues. To study the nature of tumor growth and regression, the mammary cancer model in Sprague-Dawley rats, induced by N-nitrosomethylurea(NMU) was analyzed with a view of biochemical response to physiological modification of host estradiol system, such...

Gotz, H., 1951: Successful therapy of a lupus erythematodes cum exacerbatione acuta with penicillin. Dermatologische Wochenschrift 123(24): 553-556

Janak P.H.; Martinez J.L.Jr, 1991: Posttraining cocaine or amphetamine enhances jump up active avoidance conditioning in rats. Society for Neuroscience Abstracts 17(1-2): 871

Frohberg, H.; Matthies, E., 1956: Experimental contribution to the problem of carcinoma growth and pregnancy. Zeitschrift für Geburtshilfe und Gynakologie 146(1): 1-10

Murty Y.G.K., 1972: Twentyfive years progress of geological survey in Gujarat. Mineral Wealth: Pages 1-4. 1972.

Huang, C.; Gao, Z., 2013: Associations between students' situational interest, mastery experiences, and physical activity levels in an interactive dance game. The purpose of this study was to examine the influence of previous experiences on students' situational interest and physical activity (PA) levels, as well as the relationships between situational interest and PA levels in Dance Dance Revolut...