geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Patterns of survival in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia A population-based study of 1,555 patients diagnosed in Sweden from 198 to 25


, : Patterns of survival in lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia A population-based study of 1,555 patients diagnosed in Sweden from 198 to 25.

Clinical management of lymphoplasmacytic lymphoma (LPL)/Waldenstr m macroglobulinemia (WM) has changed considerably over recent years, reflected in the use of new therapeutic agents (purine analogues, monoclonal antibodies, thalidomide- and bortezomib-based therapies). No population-based studies and few randomized trials have been performed to assess survival in newly diagnosed LPL/WM. We performed a large population-based study in Sweden including 1,555 LPL/WM patients diagnosed 1980 to 2005. Relative survival ratios (RSR) and excess mortality rate ratios (EMRR) were computed as measures of survival. Survival of LPL/WM patients has improved significantly (p=0.007) over time with 5-year RSR=0.57 (95% confidence interval 0.46-0.68), 0.65 (0.57-0.73), 0.74 (0.68-0.80), 0.72 (0.66-0.77), and 0.78 (0.71-0.85) for patients diagnosed during the calendar periods 1980-1985, 1986-1990, 1991-1995, 1996-2000, and 2001-2005, respectively. Improvement in 1- and 5-year relative survival was found in all age-groups and for LPL and WM separately. Patients with WM had lower excess mortality compared to LPL (EMRR=0.38; 95% CI 0.30-0.48). Older age at diagnosis was associated with a poorer survival (p<0.001). Taken together, we found a significant improvement in survival in LPL/WM over time. Despite this progress, new effective agents with a more favourable toxicity profile are needed to further improve survival in LPL/WM, especially in the elderly.

US$19.90

DOI: 10.1002/ajh.23351


Other references

Jin, J.; Wang, W.; Gu, T.; Chen, W.; Lu, J.; Bi, Y.; Zhu, D., 2017: The Application of SUDOSCAN for Screening Diabetic Peripheral Neuropathy in Chinese Population Screening DPN by SUDOSCAN. <b>Purpose</b> Diabetic peripheral neuropathies are the common chronic complications of diabetes, but the diagnosis is insensitive by physical examination in busy outpatients. Here we evaluated the performance of SUDOSCAN in screening...

Hesseling, S.C.rnelis; Spierings, P.T.rasius Josephus, 2004: Plug for insertion into a bone canal. A plug for insertion into a bone canal is disclosed. The plug comprises an elongate central body of substantially constant cross section carrying at least four radially extending flanges of substantially equal shape and size. The flanges form soli...

Córdoba López, A.; Monterrubio Villar, J.; Bueno Alvarez-Arenas, I.; Pérez Cidoncha, P., 2008: Hemorrhagic shock secondary to bleeding due to jejunal diverticulosis. Medicina Intensiva 32(2): 97-98

Damasceno, Bívar.P.G.L.; Dominici, V.A.; Urbano, I.A.; Silva, Jé.A.; Araújo, I.B.; Santos-Magalhães, N.S.; Silva, A.K.A.; Medeiros, A.C.; Oliveira, A.G.; Egito, E.Sócrates.T., 2012: Amphotericin B microemulsion reduces toxicity and maintains the efficacy as an antifungal product. Amphotericin B remains the drug of choice for the treatment of most of the systemic fungal infections in immunodeficient patients. Because of the high incidence of adverse drug reactions the clinical use of Amphotericin B is rather limited. To red...

Barclay, W.R., 1978: Medical care in prisons. JAMA 240(23): 2570-2570

BiCheng Yao, JingZhi Sun, AnJun Qin, Ben Zhong Tang, 2013: Thiol-yne click polymerization. Is to be further developed. In this review, we summarized recent research efforts on using thiol-yne click polymerization to synthesize polymers with topological structures. The sulfur-containing polymers were facilely prepared by photo- and therm...

Hirano H.; Nishiyama F.; Irimura T.; Fujita M., 1975: Sugar residues along the plasma membrane of the intestinal epithelial cell preliminary report. Journal of Electron Microscopy 24(3): 197-198

Chaves de Tarso, P.; Rickli, A.; Bouchereau, J.-Luc., 1998: Migration strategy of a predatory sciaenid Isopisthus parvipinnis Teleostei, Pisces in the mangrove of the Bay of Guaratuba Brazil Strategie doccupation de la mangrove de la baie de Guaratuba Bresil par le Sciaenidae predateur Isopisthus parvipinnis Teleostei, Pisces. Cahiers de Biologie Marine, 391: 63-71

Schejter, E.D.; Shilo, B.Z., 1985: Characterization of functional domains of p21 ras by use of chimeric genes. Comparison of the predicted amino acid sequences of different members of the ras family in vertebrates has shown that the N-terminal 120 residues are highly conserved while the C terminus is variable. To test the possible role of the variable resi...

Fuentes-Pila, Jé.María.; López García, E.; Calatayud, P.; Pereira, R., 2007: Clinical intervention of nicotine dependence from a systemic-relational focus. Results of a descriptive study of series of cases. We present in this work a descriptive study of series of cases in treatment for nicotine addiction with a multicomponent program focusing on a systemic-relational therapy. While a good number of smokers are able to stop smoking, with the help of d...