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Impact of obesity on survival and New York Heart Association functional class in patients with systolic heart failure


, : Impact of obesity on survival and New York Heart Association functional class in patients with systolic heart failure. Journal of the Saudi Heart Association (Elsevier) 24(4)

Several studies have shown that in patients with heart failure (HF), obesity is not associated with increased mortality, but rather is associated with improved survival. This has been referred to as the obesity paradox . To examine the impact of body mass index (BMI) on survival and New York Heart Association (NYHA) functional class in a Saudi outpatient population with chronic systolic HF. This retrospective, descriptive study, analyzed data from patients with chronic systolic HF and ejection fraction less than or equal 40% attending a Cardiovascular Disease Management program (CVDMP) over a mean follow-up of 48months. Patients were classified according to their baseline BMI. Continuous variables were presented as mean and frequencies while categorical variable presented as percentages. Risks associated with BMI groups were evaluated using multinomial logistic regression model. Mortality in the total population (n =903) was 3.3% where 47% were above age of 60 and 77% were male. Significant co-morbidities included; 67% diabetes mellitus, 67% hypertension, 12% bronchial asthma, 11% thyroid problems, 6% renal failure and 36% of patients had an EF less than 25%. BMI showed significant increase in the last follow-up compared to baseline (p <0.000). Obesity, measured by BMI, showed no statistical impact on mortality (p <0.319), but did significantly impact NYHA functional class (p <0.023). There was a chronological increase in BMI, and, although this had no significant impact on mortality, it had a significant negative impact on NYHA functional class.

US$19.90

DOI: 10.1016/j.jsha.2012.06.193


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