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Associations between high density lipoprotein mean particle size and serum paraoxonase-1 activity

, : Associations between high density lipoprotein mean particle size and serum paraoxonase-1 activity.

High density lipoprotein (HDL) particles are heterogeneous in composition, structure, size, and may differ in conferring protection against cardiovascular disease. HDL associated enzyme, paraoxonase-1 (PON1), has an important role in attenuation of atherogenic low density lipoprotein (LDL) oxidation. The aim of this study was to investigate the associations between HDL particle size and PON1 activity in relation to serum HDL cholesterol (HDL-C) levels. One hundred and forty healthy subjects contributed to this study. HDL was separated by sequential ultracentrifugation and its size was estimated by dynamic light scattering. Paraoxonase activity was measured spectrophotometrically using paraoxon as substrate. of this study showed that PON1 activity had negative correlations with HDL mean particle size(r = −0.22, P < 0.01), HDL2/HDL3 ratio, and serum HDL-C levels (r = −0.25, P < 0.01). HDL mean particle size and HDL2/HDL3 ratio had negative correlation with body mass index (BMI), waist hip ratio (WHR), and serum triglyceride (TG) levels, and positive correlation with serum HDL-C levels. Serum HDL-C levels had significant positive correlations with age, total cholesterol (TC), and apolipoprotein A-I (apo A-I) and significant negative correlation with BMI, WHR, and TG. Based on the results of this study, determination of HDL mean particle size beside the serum PON1 activity may help to better understand the CAD risks, pathogenesis, and prognosis, and may also help to design therapeutic protocols toward beneficial modifications of HDL characteristics.


Other references

Marineau, C.; Aubry, M.; Julien, J.P.; Rouleau, G.A., 1992: Dinucleotide repeat polymorphism at the D22S264 locus. Nucleic Acids Research 20(6): 1430-1430

Thase, M.E.; Montgomery, S.; Papakostas, G.I.; Bauer, M.; Trivedi, M.H.; Svedsäter, H.; Locklear, J.C.; Gustafsson, U.; Datto, C.; Eriksson, H., 2013: Quetiapine XR monotherapy in major depressive disorder: a pooled analysis to assess the influence of baseline severity on efficacy. The efficacy of quetiapine XR was investigated in patients with major depressive disorder and differing levels of baseline severity. Pooled data from four placebo-controlled monotherapy studies of quetiapine XR (50-300 mg/day) were analyzed. Post-...

Li, C-Yi.; Hsieh, C-Yen.; Lin, H-Mei.; Kao, H-Ming.; Lii, K-Hwa., 2002: High-temperature, high-pressure hydrothermal synthesis, crystal structure, and solid state NMR spectroscopy of a new vanadium(IV) silicate: Rb(2)(VO)(Si(4)O(10)).xH(2)O. A new vanadium(IV) silicate, Rb(2)(VO)(Si(4)O(10)).xH(2)O (x approximately 0.1), has been synthesized by a high-temperature, high-pressure hydrothermal method. It crystallizes in the tetragonal space group I4(1)md (No. 109) with a = 12.2225(7) A,...

Østerås, Børn.Helge.; Martinsen, A.Catrine.T.; Brandal, S.Helene.B.; Chaudhry, K.Nasreen.; Eben, E.; Haakenaasen, U.; Falk, R.Sørum.; Skaane, P., 2016: Classification of fatty and dense breast parenchyma: comparison of automatic volumetric density measurement and radiologists' classification and their inter-observer variation. Automatically calculated breast density is a promising alternative to subjective BI-RADS density assessment. However, such software needs a cutoff value for density classification. To determine the volumetric density threshold which classifies fat...

Zhang JianYun; Huang LongQuan, 2003: Distribution, movement and metabolism of vitamin B6 compounds in the silkworm, Bombyx mori. The distribution, movement and metabolism of vitamin B6 [pyridoxine] (VB6) compounds in silkworm, Bombyx mori, were studied in larvae reared on a semisynthetic diet, in which there was no mulberry powder and vitamin-free casein was the protein sou...

Perry, L., 1990: Five chosen for Hall of Fame. Modern Healthcare 20(29): 6-6

Lehman, L.B., 1993: A difficult promise. Postgraduate Medicine 93(3): 43-44

Ayala, F.; Sampogna, F.; Romano, G.V.; Merolla, R.; Guida, G.; Gualberti, G.; Paparatti, U.D.L.; Amerio, P.; Balato, N.; Potenza, C., 2015: The impact of psoriasis on work-related problems: a multicenter cross-sectional survey. Psoriasis can have cumulative physical and psychosocial effects preventing sufferers from achieving their full-life potential. Few studies have addressed the impact of psoriasis on work-related characteristics. To evaluate the impact of psoriasis...

Asmussen, E.; Mazin, B., 1978: A central nervous component in local muscular fatigue. Any activity, physical or mental, performed as diverting activity in the pauses between bouts of exhaustive muscular work had a positive effect on recuperation after fatigue. This effect was primarily of central nervous origin, and not a circulato...

Gibson, RJ.; Power, G., 1975: Selection by brook trout (Salvelinus fontinalis) and juvenile Atlantic salmon (Salmo salar) of shade related to water depth. Journal Fish Res Bd Canada, 329: 1652-1656