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Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX


, : Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX.

E-proteins are critical transcription factors in B-cell lymphopoiesis. E2A, 1 of 3 E-protein–encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein. An interaction involving a region within the N-terminal transcriptional activation domain of E2A-PBX1, termed the PCET motif, which has previously been implicated in E-protein silencing, and the KIX domain of the transcriptional coactivator CBP/p300, critical for leukemogenesis. However, the structural details of this interaction remain unknown. Here we report the structure of a 1:1 complex between PCET motif peptide and the KIX domain. Residues throughout the helical PCET motif that contact the KIX domain are important for both binding KIX and bone marrow immortalization by E2A-PBXThese results provide molecular insights into E-protein–driven differentiation of B-cells and the mechanism of E-protein silencing, and reveal the PCET/KIX interaction as a therapeutic target for E2A-PBX1–induced leukemia.

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Other references

Schechter, D.S.; Coots, T.; Zeanah, C.H.; Davies, M.; Coates, S.W.; Trabka, K.A.; Marshall, R.D.; Liebowitz, M.R.; Myers, M.M., 2005: Maternal mental representations of the child in an inner-city clinical sample: violence-related posttraumatic stress and reflective functioning. Parental mental representations of the child have been described in the clinical literature as potentially useful risk-indicators for the intergenerational transmission of violent trauma. This study explored factors associated with the quality and...

Schreiber, A.; Eisinger, M.; Storch, V., 1996: Allozymes characterize sibling species of bipolar Priapulida. Electrophoretic polymorphism of glucosephosphate isomerase (Gpi*) and phosphoglucomutase (Pgm*) polymorphisms were assayed in the bipolar-disjunct species pairs Priapulus caudatus/P. tuberculatospinosus and Priapulopsis bicaudatus/Priapulopsis aus...

Barchuk, A.S.; Semenov, I.I.; Tarakanov, S.N., 1991: Combined diagnosis of involvement of the intrathoracic lymph nodes. The paper deals with results of complex diagnosis of intrathoracic lymph node involvement in 194 patients with malignant lymphoma (85 cases), cancer (11), sarcoidosis (95) or lymphadenitis (3 cases). All the patients underwent complex roentgenolog...

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Treat, L.A., 1969: Wire suturing technic for the repair of large wounds in horses. Veterinary Medicine, Small Animal Clinician 64(1): 76-77

Yamashita, U., 1985: Effect of teleocidin on immune responses in vitro. The effect of teleocidin, a new tumor promoter, on immune responses was studied in vitro using murine lymphocytes. Teleocidin had a mitogenic and a comitogenic activity on murine lymphocytes at doses of 1-1000 ng/ml. The responder cells to teleoci...

Nielsen, B.-Schnack; Rank, F.; Engelholm, L., H.; Holm, A.; Dano, K.; Behrendt, N., 2002: Urokinase receptor-associated protein (uPARAP) is expressed in connection with malignant as well as benign lesions of the human breast and occurs in specific populations of stromal cells. The urokinase-type plasminogen activator (uPA) and the uPA receptor (uPAR) are key components in the plasminogen activation system, serving to promote specific events of extracellular matrix degradation in connection with tissue remodeling and can...

Seidner, A.G.; Spano, M.A., 1998: Asset allocation can enhance investment returns. Healthcare Financial Management 52(4): 98-99

Khalfen E.S.; Trubnikov G.A., 1970: Significance of investigation of the protein spectrum of the blood serum of patients with rheumatic fever by the methods of immuno electrophoresis and stereo immuno electrophoresis. Voprosy Revmatizma 10(2): 16-20

Satava, M.; Karlova, M.; Drevjany, L.; Slavik, L., 1970: Partial or complete replacement of chlortetracycline by zinc bacitracin in feeds for broilers. Third stage. (c) In this trial there were 22 groups of 30 chickens given no antibiotic, 60 mg chlortetracycline or 30 mg with different amounts of zinc bacitracin from 2 to 6 mg, reduced after 4 weeks for some groups and after 6 weeks for others. Other groups...