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HMG-CoA Reductase Inhibitor Statin Therapy and Coronary Atherosclerosis in Japanese Subjects


, : HMG-CoA Reductase Inhibitor Statin Therapy and Coronary Atherosclerosis in Japanese Subjects. American Journal of Cardiovascular Drugs 11(6): 411-417

The level of serum low-density lipoprotein cholesterol (LDL-C) achieved and change in serum LDL-C level in response to HMG-CoA reductase inhibitor (statin) therapy may not be reflected in coronary plaque regression in Japanese subjects, and plaque regression has occurred in many cases in the absence of any marked decrease in serum LDL-C level. We hypothesized that the indicators of coronary plaque regression in response to statin therapy in a Japanese population are different from the indicators in Western populations.The purpose of this study was to investigate the predictors of coronary plaque regression in Japanese patients with coronary artery disease (CAD) using a receiver-operating-characteristic (ROC) analysis. A 6-month prospective observational study to identify predictors of regression of coronary plaque as assessed by volumetric intravascular ultrasound was conducted on 113 CAD patients receiving usual doses of pravastatin at Nihon University Surugadai Hospital, Tokyo, Japan.The mean pravastatin dose was 12.5 3.2 mg/day. After 6 months of therapy, the average change in plaque volume was ?9.9% (p < 0.0001 vs baseline). Body mass index (BMI) before pravastatin therapy was significantly lower in the plaque regression group than in the plaque progression group (23.5 2.8 kg/m2 vs 25.3 2.5 kg/m2, p<0.01). Furthermore, significant increases in serum levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-1, and decreases in LDL-C/HDL-C, apoB/apoA-1, and monocyte count were observed in the plaque regression group (n = 90) in comparison with the plaque progression group (n = 23), while there were no differences in achieved LDL-C levels between the groups (101 25mg/dL vs 101 24mg/dL). The changes in plaque volume correlated with the changes in serum levels of HDL-C (r = ?0.496, p<0.0001), LDL-C/HDL-C (r = 0.361, p<0.0001), apoA-1 (r=?0.362, p = 0.0005), apoB/apoA-1 (r = 0.314, p = 0.0003), monocyte count (r = 0.325, p = 0.0004), and with baseline BMI (r = 0.278, p = 0.003), but not with the change in LDL-C level (r = 0.023, p = 0.860). Moreover, an ROC analysis showed that the change in HDL-C level was better than any other parameter in terms of evaluating the predictor of plaque regression because it had a larger area under the ROC curve (0.751; sensitivity: 76.9%; specificity: 60.9%; cut off value: 0%). Even with modest LDL-C lowering to maintain the serum LDL-C level at only 100mg/dL, we demonstrated that reduction of the coronary plaque volume can be achieved by elevation of the serum HDL-C. The results suggest that the ameliorating action of statins on lipid metabolism and sensitivity to their inhibitory effect on the progression of coronary plaque may be different in Japanese and Western populations.

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Other references

Wang, R.R.C., 1988: Cytological studies on a polyhaploid of Critesion iranicum obtained after hybridization with C. bulbosum. One polyhaploid (2n = 3x = 21) of C. iranicum [Hordeum brevisubulatum] (6x = 42) was obtained following hybridization with tetraploid C. bulbosum [H. bulbosum], presumably through chromosome elimination. PMCs averaged 2.43 univalents, 0.12 rod biv...

Oshiba, A.; Gelfand, E.W., 1999: Engagement of the B-cell antigen receptor by antigen negatively regulates IgE production by antigen-specific B cells. Background: Functional differentiation of B lymphocytes can be regulated at different levels. Such B-cell responses, to a large extent, are under the control of T cells and the release of soluble factors from these cells. Crosslinking of B-cell an...

Jiang RunShen; X.G.iYun; Wang XiaoLiang; Yang Ning, 2005: Broody traits of Dongxiang blue-shell chicken under floor condition. 160 chickens (aged 43 weeks) were raised in the closed hen-house with wood floor. Their brooding traits were observed by inducting egg laying to the egg-laying box. The mean nesting time was 10.5 days during the whole observation period of (0-81 d...

Ameyan, W.; Jeffery, C.; Negash, K.; Biruk, E.; Taegtmeyer, M., 2016: Attracting female sex workers to HIV testing and counselling in Ethiopia: a qualitative study with sex workers in Addis Ababa. Despite growing efforts to increase HIV testing and counselling (HTC) services for most at risk populations in Ethiopia, the use of these services by female sex workers (FSWs) remains low. With rising numbers of FSWs in Addis Ketema and concerns a...

Styczyński, T.; Pyskło, B.; Gasik, R., 2008: The effect of the grade of degenerative changes in the spine on the outcomes of surgery for lumbar discopathy with a radicular syndrome. The aim of the study was an evaluation of the influence of coexisting degenerative changes on surgical outcomes on patients with lumbar disc hernias (DH). A total of randomly selected 132 patients undergoing surgery for DH (classic discectomy with...

Leeuwen, G.J.V.n Mijnders, A.; Boot, G.W., 1966: Cooking fat composition. It is claimed that a water-free, non-spattering cooking fat of the margarine type may be obtained by incorporating a mixture preferably of 1% each of dried whey and dried milk.

Sawers, M.F.; Gilman, T.H.; Schneider, B.L.; Ellingson, E.D.; Botten, R.S.; Engelmann, W.E., 1998: Contoured adhesive wafer for ostomy appliance. Official Gazette of the United States Patent & Trademark Office Patents 1216(2): 1710, Nov 10

Shirshov, Y.I., 1971: Resistance of Rauscher's virus in milk to short-time pasteurization. Blood from mice infected with Rauscher's virus was ground with sand, diluted 1:5 with saline, the supernatant layer was diluted 1:100 with pasteurized milk and the resultant virus suspension was pasteurized in Al tubes (2.5 mm diam.) at (i) 7...

Milner, R.D.; Leach, R.N.; Ashworth, M.A.; Cser, A.; Jack, P.M., 1975: Development of pathways of insulin secretion in the rabbit. Insulin release was studied in vitro using pieces of pancreas from rabbits of between 24 days gestational age and 6 weeks postnatal age. When allowance was made for the fraction of pancreas which was endocrine, 16-5mM-glucose caused increasing sti...

Yamasaki E.N.; Rocha M.S.; Ramoa A.S., 1989: Morphology of rat retinal ganglion cells rgcs during fetal and postnatal development. Society for Neuroscience Abstracts 15(1): 455